<p>Extensive chest wall resection is often required in the management of primary or secondary chest wall tumors. Such procedures result in large full-thickness defects that demand effective reconstruction to restore chest wall stability, preserve respiratory mechanics, and protect intrathoracic structures. This study evaluates the clinical outcomes of chest wall reconstruction using a Prolene mesh and bone cement sandwich technique at a tertiary care center. This retrospective case series analyzed data from 10 patients who underwent chest wall reconstruction using the Prolene mesh and bone cement sandwich method between July 2023 and December 2024. Patient demographics, tumor pathology, defect location, surgical details, postoperative complications, and recovery outcomes were reviewed. The mean age of the patients was 56.62 years (range 45–72), with a male-to-female ratio of 7:3. Indications for surgery included lung cancer, soft tissue sarcoma, chondrosarcoma, and recurrent breast carcinoma. Most defects were located in the anterolateral or anterior chest wall. Minor complications were observed in four patients, including atelectasis, pneumonia, seroma formation, and donor site wound infection—all managed conservatively or with minor interventions. No major complications or surgery-related mortality were recorded. Six patients had uneventful recoveries. The Prolene mesh and bone cement sandwich technique is a safe, cost-effective, and structurally reliable option for reconstructing large chest wall defects. Its favorable complication profile and ease of application make it particularly suitable for use in resource-limited settings.</p>