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<p>Painful ulcers have shown high economic and epidemiologic impacts. This is a novel study to assess the analgesic effectiveness and safety of topical sevoflurane during the debridement of a painful ulcer. This study is a prospective observational study that includes 100 patients above the age of 20&#xa0;years, with chronically infected ulcers (more than 4&#xa0;weeks) associated with pain (baseline visual analog scale (VAS) score &gt; 8) of various etiologies requiring dressing/debridement. Debridement was done with IV analgesic drugs only or both IV analgesia and topical sevoflurane on alternative dressing as a crossover design. Group 1 (odd day) underwent IV analgesic alone—Injection Paracetamol 1&#xa0;g IV, and Group 2 (even day) underwent IV analgesic + topical sevoflurane—Injection Paracetamol 1&#xa0;g IV + sevoflurane topically applied. Dose of sevoflurane—1&#xa0;mL/1 cm<sup>2</sup> of ulcer area. The gauze piece was soaked with sevoflurane and kept over the ulcer for 7–10&#xa0;min before starting the dressing/debridement. The patient was kept blinded, and the VAS score was recorded every time. The mean age was 66 ± 12&#xa0;years, with female patients on the higher side. The etiology includes 38% arterial ulcers, 35% venous ulcers, and the rest traumatic ulcers. There was a significant reduction in the mean VAS scores during subsequent dressings. This novel study group had a dominant of elderly patients who were suffering from chronic ulcers. Sevoflurane was found to be beneficial in managing pain in these patients. Its use in the elderly population is particularly promising due to its potential to alleviate patients suffering from chronic ulcers. This study opens up new possibilities for utilizing sevoflurane in pain management beyond its traditional use in anesthesia.</p>

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Analgesic Effect and Safety of Topical Sevoflurane During Dressing/Debridement of Chronic Painful Ulcer: Original Article

  • 期刊论文

  • 发表日期：

    2025年4月26日

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  • Ajin Anto AK,
  • Vivek Agrawal,
  • Surjeet Dwivedi,
  • Mohneesh Pandey,
  • G. N. Tripathy,
  • Hitesh Taleja,
  • S. Anand,
  • Dinoy Chandran

摘要

Painful ulcers have shown high economic and epidemiologic impacts. This is a novel study to assess the analgesic effectiveness and safety of topical sevoflurane during the debridement of a painful ulcer. This study is a prospective observational study that includes 100 patients above the age of 20 years, with chronically infected ulcers (more than 4 weeks) associated with pain (baseline visual analog scale (VAS) score > 8) of various etiologies requiring dressing/debridement. Debridement was done with IV analgesic drugs only or both IV analgesia and topical sevoflurane on alternative dressing as a crossover design. Group 1 (odd day) underwent IV analgesic alone—Injection Paracetamol 1 g IV, and Group 2 (even day) underwent IV analgesic + topical sevoflurane—Injection Paracetamol 1 g IV + sevoflurane topically applied. Dose of sevoflurane—1 mL/1 cm2 of ulcer area. The gauze piece was soaked with sevoflurane and kept over the ulcer for 7–10 min before starting the dressing/debridement. The patient was kept blinded, and the VAS score was recorded every time. The mean age was 66 ± 12 years, with female patients on the higher side. The etiology includes 38% arterial ulcers, 35% venous ulcers, and the rest traumatic ulcers. There was a significant reduction in the mean VAS scores during subsequent dressings. This novel study group had a dominant of elderly patients who were suffering from chronic ulcers. Sevoflurane was found to be beneficial in managing pain in these patients. Its use in the elderly population is particularly promising due to its potential to alleviate patients suffering from chronic ulcers. This study opens up new possibilities for utilizing sevoflurane in pain management beyond its traditional use in anesthesia.