<p>Delayed wound healing, pain, bleeding, and discharge are common complications after anal operations which may significantly affect the patient’s quality of life and may require additional medical interventions. The primary objective was to explain symptoms that may occur after anal surgery which we describe as “Post Anal Surgery Syndrome, PASS.” The second objective of this study is to outline how to diagnose and manage those symptoms. This was a pilot study on a group of patients that developed the symptoms investigated after 1–2&#xa0;months of minor anal surgery presented to us. All patients who met the inclusion criteria were tested for the level of fecal Calprotectin, the patients with high levels were treated by Mesalamine tablets in divided doses which is described in detail in the text. The study ended up with 20 patients who met our inclusion criteria and were found to have high fecal calprotectin level (&gt; 50 mcg/g). All of them were treated by Mesalamine as discussed, revaluation was done after 6&#xa0;months. Seventeen patients (85%) showed marked improvement, and the fecal calprotectin level dropped below &gt; 50 mcg/g. The Constellation of Symptoms which may persist after simple anal operations and persist for more than 2&#xa0;months postoperatively was named as Post Anal Surgery Syndrome “PASS.” They were investigated with fecal Calprotectin and those with high levels were treated with Mesalamine and dietary restriction with an 85% cure rate.</p>