<p>There are limited studies on the prevalence of venous insufficiency in India despite its high morbidity and prolonged hospital stays. Management with elastic compressive therapy with graded pressure is a well-known conservative treatment option for this condition. This study assessed the knowledge and practice of elastic compressive therapy among patients with venous insufficiency disorder attending a tertiary healthcare center and determined the factors associated with its knowledge and practice. A cross-sectional analytical study was conducted in the Department of Surgery of a tertiary care centre. Data was collected through a questionnaire containing sociodemographic parameters, knowledge and practice of elastic compressive therapy. Patients were scored, and an arbitrary cutoff of 70% was taken as adequate knowledge and practice. A total of 80 patients were interviewed, and the results were formulated. Out of the total patients aware that stockings/bandages must be worn throughout the day, only six (8.82%) participants used them. A total of 28 participants (41.17%) were aware that the quality of stockings/bandages must be assessed regularly, but the assessment of quality of stockings/bandages was done by only five (7.35%) participants. The participants who scored less than or equal to the cutoff value of 70% in the knowledge part were daily wage labourers, indicating occupations are associated with knowledge of <i>n</i> = 30, 37.5%, <i>p</i> = 0.024. There was a significant association between socioeconomic status and practice scores (<i>n</i> = 38, 47.5%, <i>p</i> = 0.048). The study highlights that the practice mainly depends on knowledge, socioeconomic status and occupation. We found that the majority of the participants belonged to lower socioeconomic status and labourer class. A very small number of participants had adequate knowledge about elastic compression therapy, and very few of them practised it adequately.</p>