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<p>Pain and inflammation are substantial health issues that are frequently addressed with conventional medications, including indomethacin and diclofenac. Nevertheless, these medications are frequently known to have adverse side effects. As a result, the cost-effectiveness and reduced adverse effects of green-synthesized nanomaterials have garnered significant attention. Silver nanoparticles (AgNPs) synthesized with an aqueous extract of <i>Olea europaea</i> are examined in this study for their anti-inflammatory, analgesic, and cytotoxic properties. Several spectroscopic and microscopic techniques were used to characterise synthesised AgNPs. The synthesized AgNPs were incubated with HEK-293 cells for 24 h to assess their biocompatibility. The hot plate method and the acetic acid-induced writhing test were employed to evaluate the analgesic activity of AgNPs. Additionally, the anti-inflammatory potential was assessed using a carrageenan-induced paw edema model. Analgesic assessment demonstrated that the high dose of the AgNPs provided the most substantial pain relief. Furthermore, AgNPs effectively mitigated carrageenan-induced paw edema, particularly during the initial hour of inflammation. In conclusion, the results indicate that AgNPs possess significant anti-inflammatory and analgesic properties, which necessitate additional research for potential therapeutic applications.</p> Graphical abstract <p></p>

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Analgesic, anti-inflammatory and cell viability studies of silver nanoparticles synthesised using Olea europaea

  • 期刊论文

  • 发表日期：

    2026年7月6日

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  • Yanbin He,
  • Xiaoqin Li,
  • Xinyi Gou,
  • Li Wang,
  • Debing Ma,
  • Chongxiang Tong,
  • Zengwei Yang,
  • Caiyun Zhou,
  • Dian He,
  • Yujiao Chai,
  • Gopikrishna Murakonda

摘要

Pain and inflammation are substantial health issues that are frequently addressed with conventional medications, including indomethacin and diclofenac. Nevertheless, these medications are frequently known to have adverse side effects. As a result, the cost-effectiveness and reduced adverse effects of green-synthesized nanomaterials have garnered significant attention. Silver nanoparticles (AgNPs) synthesized with an aqueous extract of Olea europaea are examined in this study for their anti-inflammatory, analgesic, and cytotoxic properties. Several spectroscopic and microscopic techniques were used to characterise synthesised AgNPs. The synthesized AgNPs were incubated with HEK-293 cells for 24 h to assess their biocompatibility. The hot plate method and the acetic acid-induced writhing test were employed to evaluate the analgesic activity of AgNPs. Additionally, the anti-inflammatory potential was assessed using a carrageenan-induced paw edema model. Analgesic assessment demonstrated that the high dose of the AgNPs provided the most substantial pain relief. Furthermore, AgNPs effectively mitigated carrageenan-induced paw edema, particularly during the initial hour of inflammation. In conclusion, the results indicate that AgNPs possess significant anti-inflammatory and analgesic properties, which necessitate additional research for potential therapeutic applications.

Graphical abstract