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<p>This study investigated flavonoid extracted from <i>Quercus mongolica</i> bark (QMB-flavonoid) were evaluated for their wound healing potential. QMB-flavonoid exhibited no cytotoxicity in HaCaT cells at concentrations below 7.0&#xa0;µg/mL, maintaining over 90% cell viability. Within this safe range, QMB-flavonoid significantly inhibited 15-hydroxyprostaglandin dehydrogenase activity, leading to increased prostaglandin E₂ release (approximately 1.5-fold higher than control). It also upregulated wound healing–related genes, including KDR (about 5-fold increase), and enhanced collagen biosynthesis by more than 50% at 5.0&#xa0;µg/mL. Functional assays demonstrated accelerated wound closure in vitro (about 200% recovery compared with control), and animal experiments confirmed improved tissue regeneration with reduced epidermal thickness by the 15th day. These findings suggest that QMB-flavonoid promotes wound healing through dual mechanisms of prostaglandin metabolism regulation and extracellular matrix remodeling, supporting its potential as a natural candidate for skin regeneration therapies.</p>

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Wound healing-promoting effects of flavonoid from Quercus Mongolica via 15-PGDH Inhibition and collagen biosynthesis

  • 期刊论文

  • 发表日期：

    2025年11月27日

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  • Yulan Piao,
  • Chunyang Zhang,
  • Yue Zhang,
  • Kun Qian,
  • Ying Zhou,
  • Shufang Yang,
  • Jin Jeong,
  • Hoon Cho,
  • Young-Cheol Chang,
  • Dubok Choi

摘要

This study investigated flavonoid extracted from Quercus mongolica bark (QMB-flavonoid) were evaluated for their wound healing potential. QMB-flavonoid exhibited no cytotoxicity in HaCaT cells at concentrations below 7.0 µg/mL, maintaining over 90% cell viability. Within this safe range, QMB-flavonoid significantly inhibited 15-hydroxyprostaglandin dehydrogenase activity, leading to increased prostaglandin E₂ release (approximately 1.5-fold higher than control). It also upregulated wound healing–related genes, including KDR (about 5-fold increase), and enhanced collagen biosynthesis by more than 50% at 5.0 µg/mL. Functional assays demonstrated accelerated wound closure in vitro (about 200% recovery compared with control), and animal experiments confirmed improved tissue regeneration with reduced epidermal thickness by the 15th day. These findings suggest that QMB-flavonoid promotes wound healing through dual mechanisms of prostaglandin metabolism regulation and extracellular matrix remodeling, supporting its potential as a natural candidate for skin regeneration therapies.