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<p>In this study, an ultrasonic desorption process was developed for the efficient recovery of paclitaxel from <i>Taxus chinensis</i> culture supernatants using a commercial adsorbent, Diaion HP-20. In addition, the reusability of the adsorbent was investigated. The optimal ultrasonic power, operating time, adsorbent/solvent ratio, temperature, solvent type, and concentration for ultrasonic desorption were 180 W, 20&#xa0;min, 1:30 w/v, 25&#xa0;°C, methanol, and 100%, respectively. Furthermore, all of the paclitaxel could be recovered after three desorption cycles. The high bubble collapse intensity of acoustic cavitation played a more decisive role than the high bubble density of hydrodynamic cavitation. Diaion HP-20 maintained a high adsorption efficiency of over 95% even after five regenerations, and the stability of the adsorbent was confirmed through electron microscopy, scanning electron microscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy analyses.</p>

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Desorption and reusability of adsorbent Diaion HP-20 for the recovery of paclitaxel from culture supernatants of Taxus chinensis

  • 期刊论文

  • 发表日期：

    2025年5月6日

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  • Yeji Kang,
  • Jin-Hyun Kim

摘要

In this study, an ultrasonic desorption process was developed for the efficient recovery of paclitaxel from Taxus chinensis culture supernatants using a commercial adsorbent, Diaion HP-20. In addition, the reusability of the adsorbent was investigated. The optimal ultrasonic power, operating time, adsorbent/solvent ratio, temperature, solvent type, and concentration for ultrasonic desorption were 180 W, 20 min, 1:30 w/v, 25 °C, methanol, and 100%, respectively. Furthermore, all of the paclitaxel could be recovered after three desorption cycles. The high bubble collapse intensity of acoustic cavitation played a more decisive role than the high bubble density of hydrodynamic cavitation. Diaion HP-20 maintained a high adsorption efficiency of over 95% even after five regenerations, and the stability of the adsorbent was confirmed through electron microscopy, scanning electron microscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy analyses.