Scholarlink

<p>The extraction and recovery of 2,3-butanediol (2,3-BD) from the fermentation broth (FB) is a significant bottleneck in industrial production. Herein, we explore the hybrid aqueous two-phase extraction combined with distillation (HATPED) for recovering 2,3-BD from FB. Aqueous two-phase systems (ATPS) were selected for extraction of 2,3-BD from FB by distribution studies with different organic solvent/inorganic systems. The selected isobutanol/sodium chloride ATPS was optimized through a central composite design (CCD)-based response surface methodology (RSM) to evaluate the effects of solvent concentration, extraction temperature, and salt concentration on the 2,3-BD extraction efficiency (<i>Y</i>). The optimal extraction parameters (30% w/v sodium chloride, 40&#xa0;°C, 35% v/v isobutanol) resulted in a distribution coefficient (<i>D</i>) of 7.03 and a (<i>Y</i>) of 87%, exceeding theoretical values by 0.080%. The organic phase was processed in the distillation unit to concentrate the 2,3-BD. Scale-up experiments showed impressive extraction and recovery rates of 98.74% and 97.38%, respectively (purity &gt; 99%) in two cycles. Additionally, 85.5% of sodium chloride was recovered from the aqueous phase via evaporation. This economical and scalable approach offers valuable insights for 2,3-BD recovery from FB using organic solvent/inorganic salt via HATPED.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Enhanced 2,3-butanediol recovery from fermentation broth: a study on isobutanol/sodium chloride aqueous two-phase systems

  • 期刊论文

  • 发表日期：

    2025年3月6日

查看全文
  • Pramod Madhukar Gawal,
  • Sweta Lataye

摘要

The extraction and recovery of 2,3-butanediol (2,3-BD) from the fermentation broth (FB) is a significant bottleneck in industrial production. Herein, we explore the hybrid aqueous two-phase extraction combined with distillation (HATPED) for recovering 2,3-BD from FB. Aqueous two-phase systems (ATPS) were selected for extraction of 2,3-BD from FB by distribution studies with different organic solvent/inorganic systems. The selected isobutanol/sodium chloride ATPS was optimized through a central composite design (CCD)-based response surface methodology (RSM) to evaluate the effects of solvent concentration, extraction temperature, and salt concentration on the 2,3-BD extraction efficiency (Y). The optimal extraction parameters (30% w/v sodium chloride, 40 °C, 35% v/v isobutanol) resulted in a distribution coefficient (D) of 7.03 and a (Y) of 87%, exceeding theoretical values by 0.080%. The organic phase was processed in the distillation unit to concentrate the 2,3-BD. Scale-up experiments showed impressive extraction and recovery rates of 98.74% and 97.38%, respectively (purity > 99%) in two cycles. Additionally, 85.5% of sodium chloride was recovered from the aqueous phase via evaporation. This economical and scalable approach offers valuable insights for 2,3-BD recovery from FB using organic solvent/inorganic salt via HATPED.