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<p>In this study, a gas bubble-assisted extraction method was developed for the efficient recovery of paclitaxel from the biomass of <i>Taxus chinensis</i>. The bubble size in the extraction solution was measured by varying the gas flow rate and air sparger pore size. Furthermore, the gas bubble-assisted extraction characteristics, kinetics, and mechanism according to contact time and bubble size were investigated. The average bubble size was 2.4–6.6&#xa0;mm at gas flow rates of 1.5–5.5 L/min and air sparger pore sizes of 10–43&#xa0;µm, and the paclitaxel extraction efficiency was significantly increased as the bubble size increased. In particular, most of the paclitaxel (~ 97%) could be recovered from the biomass in just one extraction at bubble sizes of 6.4&#xa0;mm or larger. According to the intraparticle diffusion model, as the bubble size increased, the washing and diffusion steps occurred almost simultaneously, and the extraction rate constant, effective diffusion coefficient, and mass transfer coefficient increased. In addition, the external resistance for mass transfer was negligible since it had a high Biot number (&gt; 20), and the solvent and solute were efficiently mixed.</p>

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Gas bubble-assisted extraction method for efficient recovery of paclitaxel from Taxus chinensis

  • 期刊论文

  • 发表日期：

    2025年1月31日

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  • Yeji Kang,
  • Da-Yeon Kang,
  • Jin-Hyun Kim

摘要

In this study, a gas bubble-assisted extraction method was developed for the efficient recovery of paclitaxel from the biomass of Taxus chinensis. The bubble size in the extraction solution was measured by varying the gas flow rate and air sparger pore size. Furthermore, the gas bubble-assisted extraction characteristics, kinetics, and mechanism according to contact time and bubble size were investigated. The average bubble size was 2.4–6.6 mm at gas flow rates of 1.5–5.5 L/min and air sparger pore sizes of 10–43 µm, and the paclitaxel extraction efficiency was significantly increased as the bubble size increased. In particular, most of the paclitaxel (~ 97%) could be recovered from the biomass in just one extraction at bubble sizes of 6.4 mm or larger. According to the intraparticle diffusion model, as the bubble size increased, the washing and diffusion steps occurred almost simultaneously, and the extraction rate constant, effective diffusion coefficient, and mass transfer coefficient increased. In addition, the external resistance for mass transfer was negligible since it had a high Biot number (> 20), and the solvent and solute were efficiently mixed.