<p>Tissue restoration requires new load-bearing, biocompatible materials that facilitate attachment, spreading, growth, differentiation, extracellular matrix (ECM) formation, and the assessment of tissue-forming cells. Cells, scaffolds, and growth factors are commonly referred to as the tissue regeneration triad, the main constituents of engineered organs, and are typically made of polymeric biomaterials. These platforms provide organizational support for cell adhesion and subsequent organ progression. Lately, 3D printing technology has assumed a pivotal role in tissue engineering (TE), incorporating both the strategic design and manufacture of TE constructs. Moreover, poly(ε-caprolactone) (PCL) has been shown to be suitable for numerous biomedical applications due to its adaptable mechanical, biological, and physicochemical properties. It is widely used as a biocompatible material for tissue regeneration in PCL-based scaffolds. Also, the properties of PCLE can be precisely customized by integrating different nanoparticles (NPs) according to the desired application, electroactive components, or natural biomaterials to meet the demands, which can have a significant effect on the restoration and regeneration of the desired tissue, for example, bone, cartilage, cardiac, and vascular tissue. This review investigated several articles about fabricated PCL and NP scaffolds by 3D printing methods and their application in bone, cartilage, cardiac and vascular, nerve and uterine TE.</p> Graphical Abstract <p></p>