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<p>This Study explored the impact of low-intensity electrical stimulation combined with hydrogel containing VEGF and hydrogel containing serratiopeptidase on wound healing. Serratiopeptidase serves as an anti-inflammatory agent. Treated animals showed faster epithelial regeneration than the untreated control group. Hydroxyproline levels were highest in the ES+VEGF group, and histopathology supports electropathy. Daily electrical stimulation promotes cell movement, keeps the wound moist, boosts angiogenesis, and leads to healthy, scar-free skin regeneration. The independent roles of VEGF and Serratiopeptidase in promoting wound healing are well established, while electrotherapy has also demonstrated significant potential in enhancing wound closure. When VEGF is combined with low-intensity current stimulation, the healing process is further accelerated. Together, growth factors and electrotherapy synergistically enhance tissue repair, ultimately contributing to an improved quality of life for patients. This work provides evidence for a novel mechanism linking bridge between low intensity electric stimulation and growth factor based wound healing. Applications in therapeutic development. It also shows potential applications in therapeutic development.</p>

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Conductive VEGF Loaded Hydrogel Mediated Galvanotaxis with Serratiopeptidase Driven ECM Degradation: Dual-Pathway Enhancement of Wound Closure

  • 期刊论文

  • 发表日期：

    2026年4月24日

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  • Anjali Kumbhar,
  • Rikesh Dighore,
  • Sonali Nipate

摘要

This Study explored the impact of low-intensity electrical stimulation combined with hydrogel containing VEGF and hydrogel containing serratiopeptidase on wound healing. Serratiopeptidase serves as an anti-inflammatory agent. Treated animals showed faster epithelial regeneration than the untreated control group. Hydroxyproline levels were highest in the ES+VEGF group, and histopathology supports electropathy. Daily electrical stimulation promotes cell movement, keeps the wound moist, boosts angiogenesis, and leads to healthy, scar-free skin regeneration. The independent roles of VEGF and Serratiopeptidase in promoting wound healing are well established, while electrotherapy has also demonstrated significant potential in enhancing wound closure. When VEGF is combined with low-intensity current stimulation, the healing process is further accelerated. Together, growth factors and electrotherapy synergistically enhance tissue repair, ultimately contributing to an improved quality of life for patients. This work provides evidence for a novel mechanism linking bridge between low intensity electric stimulation and growth factor based wound healing. Applications in therapeutic development. It also shows potential applications in therapeutic development.