Scholarlink

<p>Persicaria viscosa (Buch.-Ham. ex D. Don), known as ‘Athalo Bishkatali’ in Bangladesh, is a medicinal herb utilized in folk medicine throughout South and Southeast Asia for treating digestive issues, infections, and inflammation. This study presents a comprehensive evaluation of the hypoglycemic, analgesic, antidiarrheal, and antioxidant activities of P. viscosa whole plant extracts using in-vitro, in-vivo, and in-silico approaches supported by GC–MS analysis. Methanolic extracts were fractionated into n-hexane (NHF), chloroform (CF), ethyl acetate (EAF), and aqueous (AQF) fractions. Hypoglycemic activity was assessed by oral glucose tolerance test, analgesic activity by tail-flick and acetic acid-induced writhing assays, antidiarrheal activity by castor oil-induced diarrhea model, and antioxidant capacity by DPPH assay. GC–MS identified 43 phytoconstituents, and molecular docking was performed against α-amylase, M1 muscarinic acetylcholine, opioid, and COX-2 receptors. Among the fractions, CF and NHF showed significant hypoglycemic effects (53.09% and 35.78% reduction at 400&#xa0;mg/kg), comparable to miglitol. AQF exhibited the highest antidiarrheal activity (53.24%), similar to loperamide (69.31%), whereas NHF and CF showed moderate effects. NHF and AQF exerted both central and peripheral analgesic actions, while CF and EAF were inactive centrally. NHF also displayed potent antioxidant activity (IC₅₀ = 29.2&#xa0;µg/mL. GC–MS analysis found 43 bioactive phytoconstituents, and molecular docking showed substantial binding affinities (–7.8 to − 10.3&#xa0;kcal/mol) of selected compounds (particularly C40 and C42) for multiple receptor targets, supporting the experimental finding. This study evaluates P. viscosa pharmacologically, validating its traditional medicinal use and suggesting its potential as a source of multi-target phytotherapeutic agents. Further research on isolation, toxicity, and mechanisms is needed to assess its clinical applicability.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Multi-Target Biological Prospects of Persicaria viscosa (Buch.-Ham. ex D. Don) Supported by GC–MS-Based Phytochemical Profiling

  • 期刊论文

  • 发表日期：

    2026年4月18日

查看全文
  • Md Alfaz Hossain,
  • Md. Shamim,
  • Md. Saiful Islam,
  • S. M. Yasin Shourav,
  • Md. Riaz Hosen,
  • Fahmida Mariam Fariha,
  • Safaet Alam,
  • Md. Rasul Karim

摘要

Persicaria viscosa (Buch.-Ham. ex D. Don), known as ‘Athalo Bishkatali’ in Bangladesh, is a medicinal herb utilized in folk medicine throughout South and Southeast Asia for treating digestive issues, infections, and inflammation. This study presents a comprehensive evaluation of the hypoglycemic, analgesic, antidiarrheal, and antioxidant activities of P. viscosa whole plant extracts using in-vitro, in-vivo, and in-silico approaches supported by GC–MS analysis. Methanolic extracts were fractionated into n-hexane (NHF), chloroform (CF), ethyl acetate (EAF), and aqueous (AQF) fractions. Hypoglycemic activity was assessed by oral glucose tolerance test, analgesic activity by tail-flick and acetic acid-induced writhing assays, antidiarrheal activity by castor oil-induced diarrhea model, and antioxidant capacity by DPPH assay. GC–MS identified 43 phytoconstituents, and molecular docking was performed against α-amylase, M1 muscarinic acetylcholine, opioid, and COX-2 receptors. Among the fractions, CF and NHF showed significant hypoglycemic effects (53.09% and 35.78% reduction at 400 mg/kg), comparable to miglitol. AQF exhibited the highest antidiarrheal activity (53.24%), similar to loperamide (69.31%), whereas NHF and CF showed moderate effects. NHF and AQF exerted both central and peripheral analgesic actions, while CF and EAF were inactive centrally. NHF also displayed potent antioxidant activity (IC₅₀ = 29.2 µg/mL. GC–MS analysis found 43 bioactive phytoconstituents, and molecular docking showed substantial binding affinities (–7.8 to − 10.3 kcal/mol) of selected compounds (particularly C40 and C42) for multiple receptor targets, supporting the experimental finding. This study evaluates P. viscosa pharmacologically, validating its traditional medicinal use and suggesting its potential as a source of multi-target phytotherapeutic agents. Further research on isolation, toxicity, and mechanisms is needed to assess its clinical applicability.

Graphical Abstract