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<p>The liver is an essential organ for detoxifying toxic substances, such as xenobiotics, and its dysfunction can lead to severe health complications. With the growing prevalence of liver diseases, the search for natural hepatoprotective agents has intensified. In this work, the ethanolic extract of <i>Euphorbia milii</i> Des Moul (EEEM) was tested for its ability to protect Wistar rat’s (Total 24 rats with <i>n</i> = 6) livers from damage caused by carbon tetrachloride (CCl<sub>4</sub>). Rats were given 200 or 400&#xa0;mg/kg body weight of EEEM orally on five consecutive days. On the second and third days, CCl<sub>4</sub> was injected intraperitoneally to cause hepatotoxicity. For comparison, a standard group was given 100&#xa0;mg/kg of Silymarin. The extract contained phenolics, flavonoids, alkaloids, glycosides and tannins, according to a phytochemical analysis. At a 50&#xa0;µg concentration, EEEM showed notable antioxidant activity in the DPPH experiment. The existence of functional groups linked to antioxidant qualities was verified by IR spectroscopy. Biochemical tests showed that, especially when given at 400&#xa0;mg/kg, EEEM dramatically restored aberrant levels of blood markers like bilirubin, total protein, albumin, globulin, ALT, ALP, and AST to a significant extent with P value &lt; 0.05. Histopathological evaluations further corroborated these findings, showing reduced hepatic tissue damage in EEEM-treated groups. These results suggest that EEEM possesses potent hepatoprotective activity, likely due to its antioxidant constituents, and may serve as a promising natural therapeutic option for liver disorders.</p> Graphical Abstract <p></p>

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Ameliorative Effect of Euphorbia milii Des Moul Leaves Against CCl4 Induced Hepatic Damage in Wistar Rats

  • 期刊论文

  • 发表日期：

    2026年4月2日

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  • Supriya Survase,
  • Raghunath Wadulkar,
  • Kranti Satpute,
  • Shoaeb Mohammad Syed

摘要

The liver is an essential organ for detoxifying toxic substances, such as xenobiotics, and its dysfunction can lead to severe health complications. With the growing prevalence of liver diseases, the search for natural hepatoprotective agents has intensified. In this work, the ethanolic extract of Euphorbia milii Des Moul (EEEM) was tested for its ability to protect Wistar rat’s (Total 24 rats with n = 6) livers from damage caused by carbon tetrachloride (CCl4). Rats were given 200 or 400 mg/kg body weight of EEEM orally on five consecutive days. On the second and third days, CCl4 was injected intraperitoneally to cause hepatotoxicity. For comparison, a standard group was given 100 mg/kg of Silymarin. The extract contained phenolics, flavonoids, alkaloids, glycosides and tannins, according to a phytochemical analysis. At a 50 µg concentration, EEEM showed notable antioxidant activity in the DPPH experiment. The existence of functional groups linked to antioxidant qualities was verified by IR spectroscopy. Biochemical tests showed that, especially when given at 400 mg/kg, EEEM dramatically restored aberrant levels of blood markers like bilirubin, total protein, albumin, globulin, ALT, ALP, and AST to a significant extent with P value < 0.05. Histopathological evaluations further corroborated these findings, showing reduced hepatic tissue damage in EEEM-treated groups. These results suggest that EEEM possesses potent hepatoprotective activity, likely due to its antioxidant constituents, and may serve as a promising natural therapeutic option for liver disorders.

Graphical Abstract