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<p><i>Gamochaeta pensylvanica</i> (Willd.) Cabrera is a medicinal plant traditionally used for managing metabolic disorders. This study evaluated the phytochemical profile, <i>in vitro</i> antioxidant and anti-diabetic activities, and <i>in vivo</i> anti-diabetic efficacy of hydroethanolic leaf extract of <i>G. pensylvanica</i> in streptozotocin-nicotinamide (STZ-NIC) induced diabetic rats. Hexane, ethyl acetate, and hydroethanolic extracts were obtained through successive solvent extraction. Phytochemical screening identified carbohydrates, terpenoids, glycosides, flavonoids, saponins, and phenolic compounds, while TLC and HPTLC analyses confirmed the presence of quercetin-like flavonoids. The hydroethanolic extract showed significant DPPH radical scavenging activity (IC50 = 246&#xa0;µg/mL) and α-amylase inhibition (66.44% at 250&#xa0;µg/mL). Acute oral toxicity studies indicated no adverse effects up to 2000&#xa0;mg/kg. <i>In vivo</i> evaluation over 21 days demonstrated that the extract significantly reduced fasting blood glucose, improved serum lipid profiles, and prevented weight loss in diabetic rats. Histopathological examination of pancreatic tissue revealed protection of β-cells. The hydroethanolic leaf extract of G. pensylvanica is rich in bioactive compounds and exhibits potent antioxidant and anti-diabetic effects, suggesting its potential as a natural therapeutic agent for diabetes management. Further studies are needed to clarify the underlying molecular mechanisms.</p> Graphical Abstract <p></p>

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Anti-Diabetic Potential of Gamochaeta pensylvanica (Willd.) Cabrera Extracts: In Vitro Enzyme Inhibition and In Vivo Evaluation in Streptozotocin–Nicotinamide-Induced Diabetic Rats

  • 期刊论文

  • 发表日期：

    2026年3月21日

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  • Hemanta Kumar Gogoi,
  • Priyanka Boruah,
  • Smriti Rekha Chanda Das,
  • Trishna Das,
  • Koyel Kar,
  • Sailee Chowdhury,
  • Priyanka Chakraborty

摘要

Gamochaeta pensylvanica (Willd.) Cabrera is a medicinal plant traditionally used for managing metabolic disorders. This study evaluated the phytochemical profile, in vitro antioxidant and anti-diabetic activities, and in vivo anti-diabetic efficacy of hydroethanolic leaf extract of G. pensylvanica in streptozotocin-nicotinamide (STZ-NIC) induced diabetic rats. Hexane, ethyl acetate, and hydroethanolic extracts were obtained through successive solvent extraction. Phytochemical screening identified carbohydrates, terpenoids, glycosides, flavonoids, saponins, and phenolic compounds, while TLC and HPTLC analyses confirmed the presence of quercetin-like flavonoids. The hydroethanolic extract showed significant DPPH radical scavenging activity (IC50 = 246 µg/mL) and α-amylase inhibition (66.44% at 250 µg/mL). Acute oral toxicity studies indicated no adverse effects up to 2000 mg/kg. In vivo evaluation over 21 days demonstrated that the extract significantly reduced fasting blood glucose, improved serum lipid profiles, and prevented weight loss in diabetic rats. Histopathological examination of pancreatic tissue revealed protection of β-cells. The hydroethanolic leaf extract of G. pensylvanica is rich in bioactive compounds and exhibits potent antioxidant and anti-diabetic effects, suggesting its potential as a natural therapeutic agent for diabetes management. Further studies are needed to clarify the underlying molecular mechanisms.

Graphical Abstract