Scholarlink

Purpose <p>Nanoneedles (NNs) represent an emerging class of minimally invasive, precise delivery platforms that integrate nanotechnology with therapeutic applications. Their ability to penetrate biological barriers—such as skin and cellular membranes—with minimal discomfort enables targeted and efficient administration of therapeutic agents. This review aims to summarize the major types, fabrication strategies, and biomedical applications of NNs while highlighting their growing impact on next-generation drug and gene delivery systems.</p> Methods <p>Through a critical review of recent literature, characteristics of solid, hollow, and porous nanoneedles were described, including the key aspects of various fabrication techniques: chemical vapor deposition (CVD), atomic layer deposition (ALD), reactive ion etching (RIE), and metal-assisted chemical etching (MACE). Key technological advancements and recent practical applications were identified by critically examining studies dealing with drug permeability enhancement, intracellular delivery performance, biosensing utility, and biocompatibility.</p> Results <p>Emerging evidence indicates that nanoneedles strongly enhance localized drug bioavailability, cellular uptake, and therapeutic response while reducing systemic exposure and pain. Approaches in fabrication, such as CVD and RIE, offer strong and uniform nanoneedle structures suited to precision delivery, while MACE provides scalable manufacturing. Nanoneedles are used in drug and gene delivery, vaccine administration, cancer therapy, cosmetics, and diagnostic biosensing, and across all these areas, they have demonstrated improved efficacy, controlled release, and precise site-specific action.</p> Conclusion <p>Nanoneedles represent a versatile and powerful delivery platform with the capability to overcome biological barriers with nanoscale accuracy. Continued innovations in design, materials, and sustainability in fabrication methods will further broaden their translational potential and place NNs as an integral element of future biomedical and pharmaceutical technologies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Nanoneedles in Modern Medicine: Emerging Frontiers in Drug Delivery, Gene Therapy, and Biosensing

  • 期刊论文

  • 发表日期：

    2026年3月18日

查看全文
  • Sakshi Bagul,
  • Ashish Patel,
  • Drashti Shah,
  • Gajanan Shinde,
  • B. K. Sridhar,
  • Aryan Patel,
  • Rajesh K.S

摘要

Purpose

Nanoneedles (NNs) represent an emerging class of minimally invasive, precise delivery platforms that integrate nanotechnology with therapeutic applications. Their ability to penetrate biological barriers—such as skin and cellular membranes—with minimal discomfort enables targeted and efficient administration of therapeutic agents. This review aims to summarize the major types, fabrication strategies, and biomedical applications of NNs while highlighting their growing impact on next-generation drug and gene delivery systems.

Methods

Through a critical review of recent literature, characteristics of solid, hollow, and porous nanoneedles were described, including the key aspects of various fabrication techniques: chemical vapor deposition (CVD), atomic layer deposition (ALD), reactive ion etching (RIE), and metal-assisted chemical etching (MACE). Key technological advancements and recent practical applications were identified by critically examining studies dealing with drug permeability enhancement, intracellular delivery performance, biosensing utility, and biocompatibility.

Results

Emerging evidence indicates that nanoneedles strongly enhance localized drug bioavailability, cellular uptake, and therapeutic response while reducing systemic exposure and pain. Approaches in fabrication, such as CVD and RIE, offer strong and uniform nanoneedle structures suited to precision delivery, while MACE provides scalable manufacturing. Nanoneedles are used in drug and gene delivery, vaccine administration, cancer therapy, cosmetics, and diagnostic biosensing, and across all these areas, they have demonstrated improved efficacy, controlled release, and precise site-specific action.

Conclusion

Nanoneedles represent a versatile and powerful delivery platform with the capability to overcome biological barriers with nanoscale accuracy. Continued innovations in design, materials, and sustainability in fabrication methods will further broaden their translational potential and place NNs as an integral element of future biomedical and pharmaceutical technologies.