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Purpose <p>Dietary lifestyle shifts toward a Western diet contribute to obesity and the rising burden of metabolic dysfunction–associated steatotic liver disease (MASLD). Non-starch polysaccharides (NSPs), particularly inulin and glucomannan, have been recognized for their fermentability, viscosity, and immunometabolic effects that ameliorate obesity-related chronic low-grade inflammation. However, the combined biological impact of highly fermentable inulin and highly viscous glucomannan on hepatic meta-inflammation has not been fully established. This study investigated the preventive effects of an inulin–glucomannan mixture on MASLD development in Western diet–fed mice.</p> Methods <p>Male C57BL/6 mice were assigned to four diet groups: standard diet (SD), high-fat diet and high-sucrose drink (HD), HD supplemented with 20% inulin (H-IO), and HD supplemented with 20% inulin + 0.5% glucomannan mixture (H-IG). After 8 weeks, metabolic profiles and hepatic steatohepatitis-related markers were evaluated.</p> Results <p>Compared with the HD group, the H-IG group exhibited significantly lower body-weight gain, reduced epididymal adiposity, improved TC/HDL-c and TG/HDL-c ratios, and attenuated MASLD scores. The NSP mixture also markedly downregulated hepatic IL-6 and CD36 protein levels, alongside <i>Lbp</i>, <i>Nfkb1</i>, and <i>Cd36</i> mRNA expression, with a large inhibitory effect on inflammatory signaling (η²<i>p</i> &gt; 0.7).</p> Conclusions <p>These findings demonstrate that combining inulin and glucomannan NSP yields a preventive metabolic benefit similar to or greater than inulin alone, mitigating Western diet-induced MASLD through modulation of hepatic meta-inflammation.</p> Graphical Abstract <p></p>

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Hepatoprotective Effects of Combined Inulin-Glucomannan Non-Starch Polysaccharide Against Western Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease

  • 期刊论文

  • 发表日期：

    2026年3月18日

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  • I Gede Putu Adhi Wedharga,
  • Made Cahyani Trisna Ananda,
  • Nadilla Faiza Richadini,
  • Bernadette Dian Novita,
  • Herjunianto Herjunianto,
  • Silvia Sutandhio,
  • Adi Pramono Hendrata,
  • Mulya Dinata,
  • Yu Hirata,
  • Suryo Kuncorojakti,
  • Hendy Wijaya,
  • Dawei Chen,
  • Ester Natalia Dorti Siagian,
  • Resa Sasmita,
  • Yudy Tjahjono,
  • Sentot Santoso

摘要

Purpose

Dietary lifestyle shifts toward a Western diet contribute to obesity and the rising burden of metabolic dysfunction–associated steatotic liver disease (MASLD). Non-starch polysaccharides (NSPs), particularly inulin and glucomannan, have been recognized for their fermentability, viscosity, and immunometabolic effects that ameliorate obesity-related chronic low-grade inflammation. However, the combined biological impact of highly fermentable inulin and highly viscous glucomannan on hepatic meta-inflammation has not been fully established. This study investigated the preventive effects of an inulin–glucomannan mixture on MASLD development in Western diet–fed mice.

Methods

Male C57BL/6 mice were assigned to four diet groups: standard diet (SD), high-fat diet and high-sucrose drink (HD), HD supplemented with 20% inulin (H-IO), and HD supplemented with 20% inulin + 0.5% glucomannan mixture (H-IG). After 8 weeks, metabolic profiles and hepatic steatohepatitis-related markers were evaluated.

Results

Compared with the HD group, the H-IG group exhibited significantly lower body-weight gain, reduced epididymal adiposity, improved TC/HDL-c and TG/HDL-c ratios, and attenuated MASLD scores. The NSP mixture also markedly downregulated hepatic IL-6 and CD36 protein levels, alongside Lbp, Nfkb1, and Cd36 mRNA expression, with a large inhibitory effect on inflammatory signaling (η²p > 0.7).

Conclusions

These findings demonstrate that combining inulin and glucomannan NSP yields a preventive metabolic benefit similar to or greater than inulin alone, mitigating Western diet-induced MASLD through modulation of hepatic meta-inflammation.

Graphical Abstract