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Purpose <p>Remodeling damaged tissues and managing infection are two crucial steps in the intricate process of the healing of chronic wounds. The present work aims to develop and enhance a rosuvastatin-loaded self-nanoemulsifying drug delivery system utilizing an active oil blend (i.e., tea tree oil, baobab oil, and sesame oil) and hyaluronic acid (RSV-HY-NE).</p> Methods <p>The RSV-HY-NE was created and optimized utilizing the Box‒Behnken statistical pattern. The formulations’ stability index and their droplet size were evaluated. The ideal formulation’s capacities to heal wounds, fight bacteria and fungi, release RSV, and exhibit ex-vivo penetration were also investigated.</p> Results <p>The droplet size of the generated nanoemulsion ranged from 25 to 327 nm. The results of the trial validated the significant synergistic effect of RSV, HY, and the active oil mixture on induced wound healing; the combination had better antibacterial and antifungal properties than earlier systems, as well as improved wound closure. The optimal formulation demonstrated an 8-fold reduction in mean wound width in comparison with a plain HY aqueous dispersion, a 5.55-fold increase in RSV penetration compared with an RSV aqueous dispersion, and a 3.4- and 3.5-fold increase in the inhibitory zone against Candida albicans and Staphylococcus aureus, respectively, compared with an oil phase containing oleic acid without the active oil mixture.</p> Conclusion <p>The developed nanoemulsions containing RSV, HY, tea tree oil, baobab oil, and sesame oil may prove to be effective paradigms for treating injuries, with enhanced antibacterial and antifungal properties.</p>

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Rosuvastatin‒Natural Oil Self Nanosized Emulsion Incorporated into Hyaluronic Acid‒Based Hydrogel for Wound Healing

  • 期刊论文

  • 发表日期：

    2026年3月5日

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  • Fayroz M. Shazly,
  • Khaled M Hosny,
  • Rasha A. Khallaf,
  • Shaimaa A. Mahmoud,
  • Walaa A. Abualsunun,
  • Abdulmajeed M. Jali,
  • Rawan Bafail,
  • Mohammed Baradwan,
  • Ahmed K. Kammoun,
  • Majed A Alghamdi,
  • Sherif El Saadany

摘要

Purpose

Remodeling damaged tissues and managing infection are two crucial steps in the intricate process of the healing of chronic wounds. The present work aims to develop and enhance a rosuvastatin-loaded self-nanoemulsifying drug delivery system utilizing an active oil blend (i.e., tea tree oil, baobab oil, and sesame oil) and hyaluronic acid (RSV-HY-NE).

Methods

The RSV-HY-NE was created and optimized utilizing the Box‒Behnken statistical pattern. The formulations’ stability index and their droplet size were evaluated. The ideal formulation’s capacities to heal wounds, fight bacteria and fungi, release RSV, and exhibit ex-vivo penetration were also investigated.

Results

The droplet size of the generated nanoemulsion ranged from 25 to 327 nm. The results of the trial validated the significant synergistic effect of RSV, HY, and the active oil mixture on induced wound healing; the combination had better antibacterial and antifungal properties than earlier systems, as well as improved wound closure. The optimal formulation demonstrated an 8-fold reduction in mean wound width in comparison with a plain HY aqueous dispersion, a 5.55-fold increase in RSV penetration compared with an RSV aqueous dispersion, and a 3.4- and 3.5-fold increase in the inhibitory zone against Candida albicans and Staphylococcus aureus, respectively, compared with an oil phase containing oleic acid without the active oil mixture.

Conclusion

The developed nanoemulsions containing RSV, HY, tea tree oil, baobab oil, and sesame oil may prove to be effective paradigms for treating injuries, with enhanced antibacterial and antifungal properties.