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<p>Despite the recent pharmaceutical advancements and dosage form modifications, the poor dissolution rates of BCS class II drugs remains a significant challenge. The aim of this study was the development of centrifugally spun drug loaded microfibers with improved dissolution rate with focus on optimizing the process variables. Drug loaded microfibers were prepared by centrifugal melt spinning (CMS) with optimized process variables (2450&#xa0;rpm, longitudinal pore shaped spinneret, 50&#xa0;cm spinneret-collector distance) using a mixture of sucrose, drug and a hydrophilic polymer, hydroxypropyl cellulose (HPC). Microfibers were characterized by using SEM, DSC, XRD and FTIR spectroscopy. Microfibers demonstrated production yield of 45 ± 4% with average diameter of 15 ± 5&#xa0;μm and disintegration time of 8 ± 2&#xa0;s. In-vitro dissolution of flurbiprofen from microfibers showed &gt; 85% release of drug within two minutes which was ∼60% more than drug alone. PXRD, DSC analysis has shown a change in crystalline nature of drug in microfibers and FTIR showed an interaction of flurbiprofen with hydrophilic excipients of formulation. This study concludes that flurbiprofen loaded microfibers showed rapid in-vitro dissolution of drug and centrifugal melt spinning is a promising approach for the production of quick release formulation of poorly soluble drug.</p>

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Fabrication of Centrifugally Spun Microfibers for Quick Release of Flurbiprofen; a Characterization and Process Optimization Study

  • 期刊论文

  • 发表日期：

    2026年3月9日

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  • Amjad Hussain,
  • Mehwish Muratab

摘要

Despite the recent pharmaceutical advancements and dosage form modifications, the poor dissolution rates of BCS class II drugs remains a significant challenge. The aim of this study was the development of centrifugally spun drug loaded microfibers with improved dissolution rate with focus on optimizing the process variables. Drug loaded microfibers were prepared by centrifugal melt spinning (CMS) with optimized process variables (2450 rpm, longitudinal pore shaped spinneret, 50 cm spinneret-collector distance) using a mixture of sucrose, drug and a hydrophilic polymer, hydroxypropyl cellulose (HPC). Microfibers were characterized by using SEM, DSC, XRD and FTIR spectroscopy. Microfibers demonstrated production yield of 45 ± 4% with average diameter of 15 ± 5 μm and disintegration time of 8 ± 2 s. In-vitro dissolution of flurbiprofen from microfibers showed > 85% release of drug within two minutes which was ∼60% more than drug alone. PXRD, DSC analysis has shown a change in crystalline nature of drug in microfibers and FTIR showed an interaction of flurbiprofen with hydrophilic excipients of formulation. This study concludes that flurbiprofen loaded microfibers showed rapid in-vitro dissolution of drug and centrifugal melt spinning is a promising approach for the production of quick release formulation of poorly soluble drug.