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<p>This study evaluated the wound-healing potential of a <i>Shorea robusta</i> (S. robusta) resin nanogel in streptozotocin-induced diabetic rats. Albumin-stabilized S. robusta nanoparticles (S-NPs) were prepared using an anti-solvent nanoprecipitation method and incorporated into a Carbopol-940 nanogel (S-NP-nanogel) with the particle size of 212 ± 12.87&#xa0;nm and the ZP to − 21 ± 0.89 mV to enhance stability, dermal penetration, and sustained release. The particles are showed spherical, evenly distributed S-NPs inside a smooth gel matrix, whereas FTIR and PXRD verified robust hydrogen-bonding interactions and semi-crystalline structure. In comparison to diabetic control, topical treatment of the S-NP-nanogel significantly decreased wound area (1.83 ± 0.04&#xa0;mm², <i>p</i> &lt; 0.001) and accelerated wound contraction (98.70 ± 9.52%). Improved oxidative balance and collagen synthesis were validated by connective tissue measures (HPR, HXA, and HUA) and antioxidant markers (GSH, LPO, and MPO). Histology showed substantial collagen deposition and full epithelialization. The higher anti-inflammatory, wound-regenerative, and antioxidant properties of the S-NP-nanogel suggested that it might be applicable as a natural treatment for diabetic wounds.</p> Graphical Abstract <p></p>

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Albumin-Stabilized Shorea robusta Resin Nanoparticles Embedded in a Nanogel for Improved Controlled Release and Diabetic Wound Healing

  • 期刊论文

  • 发表日期：

    2026年1月9日

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  • Kiran Yadav,
  • Rupinder Kaur Sodhi,
  • Ayush Sithta,
  • Ravinder Sharma,
  • Krishnaraju Venkatesan,
  • Rehab Ahmed,
  • Nizar Sirag,
  • Hassabelrasoul Elfadil,
  • Mahmoud Elodemi,
  • Jamal Moideen Muthu Mohamed

摘要

This study evaluated the wound-healing potential of a Shorea robusta (S. robusta) resin nanogel in streptozotocin-induced diabetic rats. Albumin-stabilized S. robusta nanoparticles (S-NPs) were prepared using an anti-solvent nanoprecipitation method and incorporated into a Carbopol-940 nanogel (S-NP-nanogel) with the particle size of 212 ± 12.87 nm and the ZP to − 21 ± 0.89 mV to enhance stability, dermal penetration, and sustained release. The particles are showed spherical, evenly distributed S-NPs inside a smooth gel matrix, whereas FTIR and PXRD verified robust hydrogen-bonding interactions and semi-crystalline structure. In comparison to diabetic control, topical treatment of the S-NP-nanogel significantly decreased wound area (1.83 ± 0.04 mm², p < 0.001) and accelerated wound contraction (98.70 ± 9.52%). Improved oxidative balance and collagen synthesis were validated by connective tissue measures (HPR, HXA, and HUA) and antioxidant markers (GSH, LPO, and MPO). Histology showed substantial collagen deposition and full epithelialization. The higher anti-inflammatory, wound-regenerative, and antioxidant properties of the S-NP-nanogel suggested that it might be applicable as a natural treatment for diabetic wounds.

Graphical Abstract