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Purpose <p>The current investigation aimed to assess the preventive effect of niosomal aloenin suspension on isoproterenol (ISO)-induced myocardial damage in animals.</p> Methods <p>ISO was administered in a dose of 85 mg/kg body weight (b.w.) subcutaneously for two successive days in the experimental groups, resulting in myocardial toxicity as evinced by alterations in cardiac biomarkers. Myocardial infarction (MI) is a severe disorder that can occur with extraordinary dosages or abrupt discontinuation of beta-blocker medication. The dignified considerations included cardiac glutathione (GSH), catalase (CAT), malondialdehyde (MDA), total nitrite/nitrate (NOx), and serum cardiac biomarkers: creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), alanine transaminase (ALT), and alkaline phosphatase (ALK-P). Also, tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), heme oxygenase-1 (HO-1), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), toll-like receptor 4 (TLR4), and caspase-3 activity were also assessed. Also, histopathological consideration was premeditated.</p> Results <p>Niosomal suspension of aloenin significantly inhibits oxidative stress, inflammation, and apoptosis by modulating Nrf2/HO-1/TLR4/caspase-3 signaling pathway, which exerts a positive ameliorative effect on ISO-induced MI. The histological alterations reinforced the above conclusion.</p> Conclusion <p>The findings suggest that niosomal aloenin offers meaningful protection against ISO-induced myocardial injury.</p>

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Formulation and Characterization of Niosomal Suspension of Aloenin for the Treatment of Myocardial Toxicity in Isoproterenol-Induced Rats Via Alteration HO-1/Nrf2/TLR4/ Caspase-3 Signaling Pathways

  • 期刊论文

  • 发表日期：

    2026年2月12日

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  • Samiyah Alshehri,
  • Misbahuddin Rafeeq,
  • Muhammad Afzal,
  • Alaa Hamed Habib,
  • Hadeel A Alsufyani,
  • Samy A Abusikkien,
  • Sami I. Alzarea,
  • Omar Awad Alsaidan,
  • Nadeem Sayyed,
  • Imran Kazmi

摘要

Purpose

The current investigation aimed to assess the preventive effect of niosomal aloenin suspension on isoproterenol (ISO)-induced myocardial damage in animals.

Methods

ISO was administered in a dose of 85 mg/kg body weight (b.w.) subcutaneously for two successive days in the experimental groups, resulting in myocardial toxicity as evinced by alterations in cardiac biomarkers. Myocardial infarction (MI) is a severe disorder that can occur with extraordinary dosages or abrupt discontinuation of beta-blocker medication. The dignified considerations included cardiac glutathione (GSH), catalase (CAT), malondialdehyde (MDA), total nitrite/nitrate (NOx), and serum cardiac biomarkers: creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), alanine transaminase (ALT), and alkaline phosphatase (ALK-P). Also, tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), heme oxygenase-1 (HO-1), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), toll-like receptor 4 (TLR4), and caspase-3 activity were also assessed. Also, histopathological consideration was premeditated.

Results

Niosomal suspension of aloenin significantly inhibits oxidative stress, inflammation, and apoptosis by modulating Nrf2/HO-1/TLR4/caspase-3 signaling pathway, which exerts a positive ameliorative effect on ISO-induced MI. The histological alterations reinforced the above conclusion.

Conclusion

The findings suggest that niosomal aloenin offers meaningful protection against ISO-induced myocardial injury.