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Purpose <p>Liver diseases are a major global health concern, often aggravated by environmental toxins such as carbon tetrachloride (CCl₄), which induces hepatotoxicity primarily through oxidative stress. This study evaluated the potential hepatoprotective effects of fucoidan, a sulfated polysaccharide extracted from Sargassum angustifolium, in a rat model of CCl₄-induced liver injury.</p> Methods <p>Fifty male Wistar rats were randomly allocated into five groups (<i>n</i> = 10 each): a healthy control, a CCl₄-only group, and three fucoidan treatment groups receiving 100, 150, or 200&#xa0;mg/kg orally for 28 consecutive days. Liver function biomarkers (ALT, AST, ALP, total bilirubin, and albumin), oxidative stress markers (MDA, TAC, SOD, GPx, CAT, vitamin C), and total protein were assessed at both 14 and 28 days.</p> Results <p>Fucoidan administration significantly mitigated CCl₄-induced liver injury in a dose- and time-dependent manner. Improvements included reductions in ALT, AST, ALP, and bilirubin levels, as well as restoration of albumin and total protein. Antioxidant defenses were enhanced, reflected by higher TAC, SOD, GPx, CAT, and vitamin C levels, along with decreased MDA concentrations. The 200&#xa0;mg/kg dose consistently produced the strongest effects, particularly after 28 days of treatment.</p> Conclusion <p>Fucoidan exhibited protective effects against CCl₄-induced hepatotoxicity, likely through enhancement of antioxidant defenses and stabilization of liver function markers. While these findings highlight fucoidan’s potential as a promising natural agent, the absence of histopathological and inflammatory cytokine analyses represents a limitation. Further mechanistic and histological studies are needed to confirm and extend these observations.</p>

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Hepatoprotective Effects of Fucoidan in a Carbon Tetrachloride-Induced Liver Injury Rat Model

  • 期刊论文

  • 发表日期：

    2025年10月29日

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  • Asma Dehghani,
  • Ameneh Khoshvaghti,
  • Ali Assar,
  • Ebrahim Salehizadeh,
  • Narges Obeidi,
  • Ghazal Ayatollahi,
  • Fatemeh Heidari

摘要

Purpose

Liver diseases are a major global health concern, often aggravated by environmental toxins such as carbon tetrachloride (CCl₄), which induces hepatotoxicity primarily through oxidative stress. This study evaluated the potential hepatoprotective effects of fucoidan, a sulfated polysaccharide extracted from Sargassum angustifolium, in a rat model of CCl₄-induced liver injury.

Methods

Fifty male Wistar rats were randomly allocated into five groups (n = 10 each): a healthy control, a CCl₄-only group, and three fucoidan treatment groups receiving 100, 150, or 200 mg/kg orally for 28 consecutive days. Liver function biomarkers (ALT, AST, ALP, total bilirubin, and albumin), oxidative stress markers (MDA, TAC, SOD, GPx, CAT, vitamin C), and total protein were assessed at both 14 and 28 days.

Results

Fucoidan administration significantly mitigated CCl₄-induced liver injury in a dose- and time-dependent manner. Improvements included reductions in ALT, AST, ALP, and bilirubin levels, as well as restoration of albumin and total protein. Antioxidant defenses were enhanced, reflected by higher TAC, SOD, GPx, CAT, and vitamin C levels, along with decreased MDA concentrations. The 200 mg/kg dose consistently produced the strongest effects, particularly after 28 days of treatment.

Conclusion

Fucoidan exhibited protective effects against CCl₄-induced hepatotoxicity, likely through enhancement of antioxidant defenses and stabilization of liver function markers. While these findings highlight fucoidan’s potential as a promising natural agent, the absence of histopathological and inflammatory cytokine analyses represents a limitation. Further mechanistic and histological studies are needed to confirm and extend these observations.