Purpose <p>Chronic diabetic wounds are characterized by prolonged inflammation and impaired healing. This study evaluates a novel polyherbal ointment, W Cura D Plus^®, which contains <i>Azadirachta indica</i> oil, <i>Hypericum perforatum</i> oil, and bromelain from <i>Ananas comosus</i>. After initial debridement with W Cura D Plus^®, treatment continued with W Cura G Plus^®. To our knowledge, this is the first clinical report examining this specific combination in the treatment of chronic diabetic wounds.</p> Methods <p>A single-center clinical case series was conducted in 13 diabetic patients with Wagner grade 2–3 diabetic foot ulcers of at least 4 weeks’ duration. All patients were on standard type 2 diabetes therapy (oral agents and/or insulin) and routine wound care prior to enrollment. W Cura D Plus^® was applied daily for 7 days to promote debridement, followed by W Cura G Plus^® until complete closure or no further reduction in ulcer size for two consecutive weeks. Clinical endpoints included wound area, closure percentage, and recovery time. White blood cell (WBC) and C-reactive protein (CRP) levels were monitored.</p> Results <p>Fourteen wound observations were analyzed. Mean wound area decreased from 25.07 ± 24.56&#xa0;cm² at baseline to 7.38 ± 5.15&#xa0;cm² (<i>p</i> = 0.0103), and mean closure rate was 64.15 ± 0.23% (<i>p</i> = 0.0108), surpassing the 50% benchmark for clinically meaningful improvement. Recovery time averaged 97.7 days compared to baseline (initial status prior to treatment). WBC and CRP significantly declined (<i>p</i> &lt; 0.0001). No adverse events were reported.</p> Conclusion <p>This polyherbal formulation may represent a safe adjunct to standard care, but larger controlled trials are needed to confirm efficacy.</p>