<p>Silkworm silk has gained recognition as a copious biopolymer with a number of alluring properties since it was initially found more than 4,000 years ago. Silk fibroin (SF), the primary protein found in silkworm silk, is utilized in several technical development processes, most notably tissue engineering and the production of biomaterials for drug delivery systems. Its applications are not limited to the textile industry. Despite its beneficial curative effects, traditional Chinese medicine (TCM) has several disadvantages, such as complex ingredients, unstable medications, potential drug interactions, and more.Developing a unique drug delivery method that can load Chinese medicine monomers (CMM) is critical to resolving this issue. By employing SF as a carrier material to transport CMM, innovative CDDS that considerably improve sickness treatment without incurring harmful side effects can be developed. To assess and evaluate new research findings and successes, a study of silk fibroin as a loading CMM carrier material is important. Our work thoroughly investigates and assesses recent research on novel medication delivery methods based on SF and TCM monomers. Recently, SF’s outstanding mechanical properties—such as ease of manufacture, excellent biocompatibility, controlled biodegradation, and customizable fictionalization have enabled cutting-edge applications. This review examines the structure, content, fundamental qualities, and relationship between structure and attributes in science fiction, as well as a brief explanation of procedures for making and modifying diverse materials. Furthermore, we address our future plans for SF-based materials in TCM biologic delivery, gene therapy, wound healing, and bone regeneration applications.</p> Graphical Abstract <p>Applications of Silk Fibroin</p> <p></p>