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Background <p>Scalp psoriasis affects a significant portion of psoriasis patients and can be exacerbated by conventional hair dyes. This study aimed to develop a dual-purpose nanosuspension hair dye formulation containing methotrexate for simultaneous treatment and hair coloring.</p> Methods <p>Methotrexate nanosuspensions were prepared using the precipitation-ultrasonication method, incorporating beetroot powder as a natural coloring agent. The formulation was characterized using FT-IR, DSC, particle size and zeta potential measurements, SEM, in vitro drug release studies, pH determination, and drug content analysis. The coloring ability and color stability were also evaluated.</p> Results <p>FT-IR and DSC confirmed drug-excipient compatibility. The nanosuspension had a particle size of 154&#xa0;nm and a zeta potential of -29 mV. SEM revealed a generally spherical particle morphology. In vitro drug release showed 86% release in 1&#xa0;h. The formulation pH was 5.89, and the drug content was 96%. The formulation effectively colored grey hair reddish and enhanced the luster of black hair. The color was stable against sunlight but faded after 6–8 washes with gentle shampoo.</p> Conclusion <p>A methotrexate-loaded nanosuspension hair dye formulation is feasible and shows potential for treating scalp psoriasis while coloring hair.</p>

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Enhanced Delivery of Methotrexate for Scalp Psoriasis Treatment via Nanosuspension Hair Dye: A Box-Behnken Optimization Approach

  • 期刊论文

  • 发表日期：

    2025年10月20日

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  • Poojitha P.N.,
  • Akhil Perumalla,
  • Sandhya Rachamalla,
  • shirisha Mandli,
  • Shilpa Ajje,
  • Sindura Talari,
  • Shaik Afroz Kottapalli,
  • Nagashubha B,
  • M. Kiran Sai

摘要

Background

Scalp psoriasis affects a significant portion of psoriasis patients and can be exacerbated by conventional hair dyes. This study aimed to develop a dual-purpose nanosuspension hair dye formulation containing methotrexate for simultaneous treatment and hair coloring.

Methods

Methotrexate nanosuspensions were prepared using the precipitation-ultrasonication method, incorporating beetroot powder as a natural coloring agent. The formulation was characterized using FT-IR, DSC, particle size and zeta potential measurements, SEM, in vitro drug release studies, pH determination, and drug content analysis. The coloring ability and color stability were also evaluated.

Results

FT-IR and DSC confirmed drug-excipient compatibility. The nanosuspension had a particle size of 154 nm and a zeta potential of -29 mV. SEM revealed a generally spherical particle morphology. In vitro drug release showed 86% release in 1 h. The formulation pH was 5.89, and the drug content was 96%. The formulation effectively colored grey hair reddish and enhanced the luster of black hair. The color was stable against sunlight but faded after 6–8 washes with gentle shampoo.

Conclusion

A methotrexate-loaded nanosuspension hair dye formulation is feasible and shows potential for treating scalp psoriasis while coloring hair.