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<p>3D printing of pharmaceuticals is an emerging field, which will have many exciting applications in the sphere of personalised medicine. The inherent advantages are that it offers manufacturing flexibility and platform versatility. However, there is limited mechanistic understanding of the dissolution behaviour of these novel dosage forms. In this study, Near Infrared (NIR) and Raman mapping techniques were used in conjunction with a custom dissolution flow cell to gather spatially resolved, real-time dissolution data of two geometries of 3D printed tablets. Caffeine was used as a model drug compound in a polymer filament. Two geometries of tablets were printed using Fused Filament Modelling (FFM); one solid tablet and one with vertical and horizontal channels. Chemical mapping facilitated simultaneous tracking of water ingress and drug distribution. The data obtained from this approach establishes a platform to assess the release mechanisms of many novel formulations and geometries of 3D printed pharmaceuticals to come.</p>

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In Situ Evaluation of Drug Release and Water Ingress from 3D Printed Tablets Via Near Infrared and Raman Mapping

  • 期刊论文

  • 发表日期：

    2025年9月26日

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  • Zoë J Whalley,
  • Tom Mills,
  • Richard Greenwood,
  • Patrick Wray

摘要

3D printing of pharmaceuticals is an emerging field, which will have many exciting applications in the sphere of personalised medicine. The inherent advantages are that it offers manufacturing flexibility and platform versatility. However, there is limited mechanistic understanding of the dissolution behaviour of these novel dosage forms. In this study, Near Infrared (NIR) and Raman mapping techniques were used in conjunction with a custom dissolution flow cell to gather spatially resolved, real-time dissolution data of two geometries of 3D printed tablets. Caffeine was used as a model drug compound in a polymer filament. Two geometries of tablets were printed using Fused Filament Modelling (FFM); one solid tablet and one with vertical and horizontal channels. Chemical mapping facilitated simultaneous tracking of water ingress and drug distribution. The data obtained from this approach establishes a platform to assess the release mechanisms of many novel formulations and geometries of 3D printed pharmaceuticals to come.