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Purpose <p>To make effervescent tablet which being able to used for large doses of active ingredient, improve palatability, and simplify the manufacture of an effervescent tablet containing roasted banana peel extract (RBPE) via hot melt extrusion, and to optimise its formulation while assessing its antidepressant activity.</p> Methods <p>Effervescent granules were produced by hot melt extrusion and compressed directly into tablets. Optimisation employed a two-factor, two-level factorial design, with crospovidone (8–10% w/w) and effervescent base (50–55% w/w) as independent variables. The antidepressant activity of the optimised formulation was evaluated in mice using the forced-swim test (FST) and tail-suspension test (TST).</p> Results <p>A higher crospovidone concentration significantly shortened disintegration time (<i>p</i> &lt; 0.05). The proportion of effervescent base, and its interaction with crospovidone, significantly affected tablet hardness and friability (<i>p</i> &lt; 0.05). In both the FST and TST, the optimised RBPE tablet reduced immobility time to the same extent as fluoxetine and crude RBPE, indicating comparable antidepressant efficacy.</p> Conclusions <p>The optimised RBPE effervescent tablet disintegrated rapidly, met physical quality specifications, and exhibited significant antidepressant activity, supporting its potential as a convenient dosage form for RBPE.</p>

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Formulation, Optimization, and In Vitro Studies of Roasted Agung Banana var. Semeru Peel Effervescent Antidepressant Tablet

  • 期刊论文

  • 发表日期：

    2025年7月12日

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  • Lannie Hadisoewignyo,
  • Dwi Qonita Safitri,
  • Restry Sinansari,
  • Jefri Prasetyo,
  • Kevin Owen Santoso,
  • Salwa Damayanti,
  • Dilla Sonia Wahyu Afotia,
  • Ivonne Soeliono

摘要

Purpose

To make effervescent tablet which being able to used for large doses of active ingredient, improve palatability, and simplify the manufacture of an effervescent tablet containing roasted banana peel extract (RBPE) via hot melt extrusion, and to optimise its formulation while assessing its antidepressant activity.

Methods

Effervescent granules were produced by hot melt extrusion and compressed directly into tablets. Optimisation employed a two-factor, two-level factorial design, with crospovidone (8–10% w/w) and effervescent base (50–55% w/w) as independent variables. The antidepressant activity of the optimised formulation was evaluated in mice using the forced-swim test (FST) and tail-suspension test (TST).

Results

A higher crospovidone concentration significantly shortened disintegration time (p < 0.05). The proportion of effervescent base, and its interaction with crospovidone, significantly affected tablet hardness and friability (p < 0.05). In both the FST and TST, the optimised RBPE tablet reduced immobility time to the same extent as fluoxetine and crude RBPE, indicating comparable antidepressant efficacy.

Conclusions

The optimised RBPE effervescent tablet disintegrated rapidly, met physical quality specifications, and exhibited significant antidepressant activity, supporting its potential as a convenient dosage form for RBPE.