Purpose <p>Toxicity of the biomaterials is one of the most important parameters that is considered while choosing a biopolymer for drug delivery and other biomedical applications. In this context, biodegradable polymer hydrogel plays an important role due to their high porosity, high drug loading, controlled drug release, and biocompatibility. These materials offer a safer alternative to synthetic polymers, minimizing long-terms side effects and eliminating the need for surgical removal. Biopolymer based hydrogels also mimic the natural extracellular matrix, making them suitable for tissue regeneration. Additionally, the incorporation of bioactive agents such as plant extracts and metal oxide nanoparticles enhances their functional properties for application in the biomedical field. Thus, the development of multifunctional biodegradable hydrogels is crucial for advancing modern drug delivery systems and tissue regeneration technologies.</p> Methods <p>The present study investigated the swelling index, porosity, drug loading efficiency, drug release profile, kinetics, and hydrogel degradation kinetics. Characterization was performed using XRD and SEM to confirm structural properties.</p> Results <p>The results from the study demonstrated that CS/PV/Ni/SCE had high swelling potential (1261%), higher porosity (71.67%), high drug loading capacity (93.91%), and sustained drug release behavior (64.46%). Furthermore, the developed hydrogel has a good degradation rate i.e. 70.88% at standard lab conditions.</p> Conclusion <p>The results from the study demonstrate that the produced CS/PV/Ni/SCE polymer hydrogel is a promising candidate for drug delivery and tissue engineering applications. Due to its high porosity and sustained drug properties, it can act as biodegradable scaffold in crucial wound healing treatments where toxicity of the material is a major problem. Secondly it can be used in critical surgeries where scaffold removal is necessary due to its self-degradation property.</p>