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Purpose <p>The present investigation aims to formulate a polyherbal lollipops incorporating Neem (<i>Azadirachta indica</i>), Clove (<i>Syzygium aromaticum</i>), Ginger (<i>Zingiber officinale</i>) extract to combat dental problems of Oral Thrush and Periodontal Disease.</p> Methods <p>Such lollipops were successfully prepared by using heating and congealing method using 23 full factorial design approach. Sucrose, Methyl Cellulose and corn syrup were considered as independent variables and their effect was studied on Hardness, drug release and disintegration time considering as a dependent variable.</p> Result <p>The optimized formulation was found to be symmetrical, smooth, and clear with shiny surfaces and no inconsistencies. The hardness and disintegration time of formulation with increasing concentration ranges between 6 (Kg/cm.sq) -14 (Kg/cm.sq) and 7.56&#xa0;min to 14.11&#xa0;min. whereas the drug release was found in between 25.34 ± 2.3% to 89.01 ± 1.9%. After evaluating formulation it has been found that level of independent variables positively affects the Hardness and disintegration time while negatively affects drug release.</p> Conclusion <p>The formulation showed enhanced antifungal (<i>candida albicans</i>) and anti-bacterial (<i>streptococcus mutans</i>) activities when compared with standard drugs of Ketoconazole and Erythromycin respectively.</p>

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Design, Development and Evaluation of Polyherbal Lollipops Formulation for the Treatment of Oral Thrush and Periodontal Disease

  • 期刊论文

  • 发表日期：

    2025年3月26日

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  • Rushikesh Kshirsagar,
  • Varsha Balkrishna Mane,
  • Nagesh Aloorkar,
  • Divya Bhagat,
  • Sanuja Kadam,
  • Sagar Pathade

摘要

Purpose

The present investigation aims to formulate a polyherbal lollipops incorporating Neem (Azadirachta indica), Clove (Syzygium aromaticum), Ginger (Zingiber officinale) extract to combat dental problems of Oral Thrush and Periodontal Disease.

Methods

Such lollipops were successfully prepared by using heating and congealing method using 23 full factorial design approach. Sucrose, Methyl Cellulose and corn syrup were considered as independent variables and their effect was studied on Hardness, drug release and disintegration time considering as a dependent variable.

Result

The optimized formulation was found to be symmetrical, smooth, and clear with shiny surfaces and no inconsistencies. The hardness and disintegration time of formulation with increasing concentration ranges between 6 (Kg/cm.sq) -14 (Kg/cm.sq) and 7.56 min to 14.11 min. whereas the drug release was found in between 25.34 ± 2.3% to 89.01 ± 1.9%. After evaluating formulation it has been found that level of independent variables positively affects the Hardness and disintegration time while negatively affects drug release.

Conclusion

The formulation showed enhanced antifungal (candida albicans) and anti-bacterial (streptococcus mutans) activities when compared with standard drugs of Ketoconazole and Erythromycin respectively.