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Purpose <p>Breast cancer (BC) remains the leading cause of cancer-related mortality among women. This study aimed to improve the solubility, stability, and therapeutic efficacy of Resveratrol (RES) by developing an electrospun nanofiber mat for targeted drug delivery to breast tissue.</p> Methods <p>RES was incorporated into an inclusion complex with sulfobutylether β-cyclodextrin (SBE-β-Cyd) and polyvinylpyrrolidone (PVP K90). Polymer selection was guided by molecular docking and solution-state stability studies. The nanofibers were characterized using FTIR, DSC, XRD, and SEM, and evaluated for entrapment efficiency, moisture content, contact angle, and tensile strength. In vitro and ex vivo studies assessed drug release in phosphate buffer (pH 7.4) and biocompatibility using the HET-CAM assay. Antioxidant activity was analyzed via the DPPH assay, while anticancer potential was tested against MCF-7 breast cancer cells.</p> Results <p>The nanofibers demonstrated sustained RES release, enhanced solubility, and improved skin permeation. Biocompatibility studies confirmed their non-irritant nature and antioxidant assays showed maintained activity. Cytotoxicity assays indicated that RES-loaded nanofibers exhibited significant anticancer effects against MCF-7 cells, surpassing pure RES.</p> Conclusion <p>The developed RES-loaded nanofiber mat presents a promising localized treatment for breast cancer by overcoming RES’s solubility and stability limitations. The formulation enables sustained drug release and enhanced therapeutic efficacy, warranting further in vivo investigations to validate its clinical potential.</p>

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Formulation and Development of Resveratrol-Loaded Sulfobutylether β-Cyclodextrin and PVP K90-Based Nanofiber Mat Via Electrospinning for the Breast Cancer Therapy

  • 期刊论文

  • 发表日期：

    2025年3月6日

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  • Priyanka Shinde,
  • Amol Shete,
  • Vishwajeet Ghorpade,
  • Namdev Harale,
  • Swapnali Patil,
  • Namrata Desai,
  • Snehal Patil

摘要

Purpose

Breast cancer (BC) remains the leading cause of cancer-related mortality among women. This study aimed to improve the solubility, stability, and therapeutic efficacy of Resveratrol (RES) by developing an electrospun nanofiber mat for targeted drug delivery to breast tissue.

Methods

RES was incorporated into an inclusion complex with sulfobutylether β-cyclodextrin (SBE-β-Cyd) and polyvinylpyrrolidone (PVP K90). Polymer selection was guided by molecular docking and solution-state stability studies. The nanofibers were characterized using FTIR, DSC, XRD, and SEM, and evaluated for entrapment efficiency, moisture content, contact angle, and tensile strength. In vitro and ex vivo studies assessed drug release in phosphate buffer (pH 7.4) and biocompatibility using the HET-CAM assay. Antioxidant activity was analyzed via the DPPH assay, while anticancer potential was tested against MCF-7 breast cancer cells.

Results

The nanofibers demonstrated sustained RES release, enhanced solubility, and improved skin permeation. Biocompatibility studies confirmed their non-irritant nature and antioxidant assays showed maintained activity. Cytotoxicity assays indicated that RES-loaded nanofibers exhibited significant anticancer effects against MCF-7 cells, surpassing pure RES.

Conclusion

The developed RES-loaded nanofiber mat presents a promising localized treatment for breast cancer by overcoming RES’s solubility and stability limitations. The formulation enables sustained drug release and enhanced therapeutic efficacy, warranting further in vivo investigations to validate its clinical potential.