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<p>Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by inflammation due to autoantibodies against nuclear antigens. Current treatments suffer from poor bioavailability, low specificity, and significant side effects. Nanoparticle (NP)-based drug delivery systems offer promising alternatives through enhancing solubility, stability, bioavailability, controlled release and targeted delivery of drugs. Recent studies have demonstrated that NPs with various structures provide a novel approach for treating SLE, potentially reducing side effects while improving efficacy of therapeutic agents. This review aims to present the current status of SLE therapy, along with the potential advantages and challenges of using NPs in diagnosis and treatment of SLE.</p>

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A Review on the Treatment and Diagnosis of Systemic Lupus Erythematosus Using Nanoparticle Systems

  • 期刊论文

  • 发表日期：

    2025年3月12日

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  • Amin Seddigh,
  • Zahra Salmasi,
  • Fatemeh Kalalinia,
  • Somayeh Marouzi,
  • Maryam Hashemi

摘要

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by inflammation due to autoantibodies against nuclear antigens. Current treatments suffer from poor bioavailability, low specificity, and significant side effects. Nanoparticle (NP)-based drug delivery systems offer promising alternatives through enhancing solubility, stability, bioavailability, controlled release and targeted delivery of drugs. Recent studies have demonstrated that NPs with various structures provide a novel approach for treating SLE, potentially reducing side effects while improving efficacy of therapeutic agents. This review aims to present the current status of SLE therapy, along with the potential advantages and challenges of using NPs in diagnosis and treatment of SLE.