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Purpose <p>Three-dimensional (3D) printing is revolutionising tablet fabrication in the field of pharmacy, offering personalised dosing through additive manufacturing techniques such as semi-solid extrusion (SSE). SSE traditionally uses disposable syringes, which pose challenges in temperature control and waste generation.</p> Methods <p>This article experimentally simulates various scenarios relevant to pharmacy practice to evaluate the usability of the semi-solid extrusion approach using a first-of-its-kind reusable cartridge. The research assesses the stability of formulations under thermal stress conditions that simulate commercial settings, demonstrating the robust performance of this 3D drug printing method across multiple uses.</p> Results <p>This study introduces pharmaceutical-grade stainless-steel cartridges as a sustainable alternative to disposable syringes, enhancing temperature management and reducing waste in SSE 3D printing.</p> Conclusion <p>Our findings highlight the potential of reusable cartridges to improve efficiency and sustainability in pharmaceutical manufacturing, with implications for future formulation developments and stability studies. The presented 3D drugprinting approach offers a promising solution for environmentally responsible practices in pharmacy.</p>

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3D Drug Printing by Semi-Solid Extrusion Through Reusable Cartridges: Usability Evaluation

  • 期刊论文

  • 发表日期：

    2025年1月22日

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  • Rohan Rege,
  • Tessa Mellema,
  • Arwin Ramcharan,
  • Anouar Ait Hoummad,
  • Sophie Verhoeven,
  • Vibhas Mishra,
  • Arjen J. Jansen,
  • Niels Ouwerkerk,
  • Fereshteh Shokri

摘要

Purpose

Three-dimensional (3D) printing is revolutionising tablet fabrication in the field of pharmacy, offering personalised dosing through additive manufacturing techniques such as semi-solid extrusion (SSE). SSE traditionally uses disposable syringes, which pose challenges in temperature control and waste generation.

Methods

This article experimentally simulates various scenarios relevant to pharmacy practice to evaluate the usability of the semi-solid extrusion approach using a first-of-its-kind reusable cartridge. The research assesses the stability of formulations under thermal stress conditions that simulate commercial settings, demonstrating the robust performance of this 3D drug printing method across multiple uses.

Results

This study introduces pharmaceutical-grade stainless-steel cartridges as a sustainable alternative to disposable syringes, enhancing temperature management and reducing waste in SSE 3D printing.

Conclusion

Our findings highlight the potential of reusable cartridges to improve efficiency and sustainability in pharmaceutical manufacturing, with implications for future formulation developments and stability studies. The presented 3D drugprinting approach offers a promising solution for environmentally responsible practices in pharmacy.