Comolia ciliata is a new species endemic to the Colombian Amazon, occuring in the quartzitic sand savannas near the headwaters of the Cuduyarí River, in the Department of Vaupés, and also in the Serranía La Lindosa, in the Department of Guaviare. This species is described, illustrated, and compared with its most similar congeners, C. leptophylla and C. prostrata. Comolia ciliata is primarily known from two collections made by Richard Evans Schultes in the 1950s and 1960s, and from additional collections made in the early 2000s. Comolia ciliata is preliminarily categorized as Endangered according to IUCN criteria.