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<p>Antimicrobial resistance (AMR) of <i>Neisseria gonorrhoeae</i> is a global public health concern. This resistance may result from the presence of plasmid-encoded proteins or mutations within chromosomal genes. Tetracyclines are used in post-exposure prophylaxis (PEP) of sexually transmitted infections (STIs), especially in high-risk populations. In this study, the susceptibility of 116 <i>N. gonorrhoeae</i> strains to penicillin and tetracycline was evaluated. Plasmid-mediated resistance was determined using both phenotypic and molecular methods. Among the analysed strains, 15 (12.9%) and 47 (40.5%) were resistant to penicillin and tetracycline, respectively. Plasmid-mediated resistance to penicillin and/or tetracycline was confirmed in 27 (23.3%) strains. The <i>blaTEM</i> gene of the African type was detected in all PPNG strains, while the <i>tetM</i> gene of either the Dutch or American variant was identified in HLTR strains. A statistically significant correlation between the presence of <i>blaTEM</i> and <i>tetM</i> plasmid-encoded resistance genes suggests a potential cooccurrence of resistance mechanisms within the gonococcal population. The strains with plasmid-mediated resistance were classified into 14 NG-MAST sequence types (STs), with ST11461 and ST14769 being the most common.</p>

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Plasmid-mediated resistance in Neisseria gonorrhoeae clinical strains from South Poland, 2014–2021

  • 期刊论文

  • 发表日期：

    2026年2月28日

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  • Joanna Białecka,
  • Katarzyna Rak,
  • Anna Białecka,
  • Aneta Kiecka,
  • Danuta Rojek-Zakrzewska,
  • Monika Brzychczy-Włoch,
  • Barbara Zawilińska

摘要

Antimicrobial resistance (AMR) of Neisseria gonorrhoeae is a global public health concern. This resistance may result from the presence of plasmid-encoded proteins or mutations within chromosomal genes. Tetracyclines are used in post-exposure prophylaxis (PEP) of sexually transmitted infections (STIs), especially in high-risk populations. In this study, the susceptibility of 116 N. gonorrhoeae strains to penicillin and tetracycline was evaluated. Plasmid-mediated resistance was determined using both phenotypic and molecular methods. Among the analysed strains, 15 (12.9%) and 47 (40.5%) were resistant to penicillin and tetracycline, respectively. Plasmid-mediated resistance to penicillin and/or tetracycline was confirmed in 27 (23.3%) strains. The blaTEM gene of the African type was detected in all PPNG strains, while the tetM gene of either the Dutch or American variant was identified in HLTR strains. A statistically significant correlation between the presence of blaTEM and tetM plasmid-encoded resistance genes suggests a potential cooccurrence of resistance mechanisms within the gonococcal population. The strains with plasmid-mediated resistance were classified into 14 NG-MAST sequence types (STs), with ST11461 and ST14769 being the most common.