Scholarlink

<p>The fungal pathogen <i>Candida albicans</i> produces numerous surface proteins involved in adhesion. Many of these adhesins are specific to different morphological forms. Strains that are unable to form hyphae are generally impaired in their ability to adhere to surfaces and to form biofilms. To better understand the function of one of these adhesins, Als3p, in the context of yeast-locked strains, we expressed <i>ALS3</i> in strains with altered expression of one of two genes that are part of a regulatory circuit, <i>BRG1</i> and <i>NRG1</i>. The mutant <i>BRG1</i> and <i>NRG1</i> strains we examined were phenotypically similar. We observed that <i>ALS3</i> expression improved the adhesion of both strains to glass but that only one had altered biofilm forming ability, which was decreased.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Constitutive ALS3 expression in Candida albicans has differential effects on yeast-locked tet-NRG1 and brg1Δ strains

  • 期刊论文

  • 发表日期：

    2025年7月1日

查看全文
  • Nicholas C. Schena,
  • Kassandra M. Baker,
  • Anna A. Stark,
  • Derek P. Thomas,
  • Ian A. Cleary

摘要

The fungal pathogen Candida albicans produces numerous surface proteins involved in adhesion. Many of these adhesins are specific to different morphological forms. Strains that are unable to form hyphae are generally impaired in their ability to adhere to surfaces and to form biofilms. To better understand the function of one of these adhesins, Als3p, in the context of yeast-locked strains, we expressed ALS3 in strains with altered expression of one of two genes that are part of a regulatory circuit, BRG1 and NRG1. The mutant BRG1 and NRG1 strains we examined were phenotypically similar. We observed that ALS3 expression improved the adhesion of both strains to glass but that only one had altered biofilm forming ability, which was decreased.