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<p>The genus <i>Escherichia</i> comprises seven species, including <i>Escherichia marmotae</i>, described in 2015 from the feces of healthy Himalayan marmots (<i>Marmota himalayana</i>). This species exhibits atypical biochemical properties, such as negative lactose fermentation and indole production. The pathogenic potential of <i>E. marmotae</i> is demonstrated by its ability to invade epithelial cells and the presence of virulence genes. The first human infections with <i>E. marmotae</i> were recorded in Norway in 2021. This article describes the case of a 64-year-old man undergoing chemotherapy for urinary tract cancer, who was hospitalized with febrile neutropenia. An infection caused by <i>E. marmotae</i> and <i>K. pneumoniae</i> was detected. Laboratory diagnostics revealed a multidrug-resistant strain of <i>E. coli</i> producing KPC-type carbapenemase, subsequently identified as <i>E. marmotae</i> by MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry) and confirmed by 16S rRNA sequencing and whole genome sequencing. Biochemical tests indicated similarities to <i>E. coli</i>. Virulence analysis revealed the presence of genes typical of pathogenic strains of <i>E. coli</i>. This case report is the first documented instance of <i>E. marmotae</i> in the Czech Republic and highlights the difficulty of distinguishing this species from <i>E. coli</i> in routine diagnostics. Accurate identification requires advanced methods such as MALDI-TOF and sequencing analysis.</p>

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Escherichia marmotae: a multidrug-resistant opportunistic human pathogen — first clinical isolation in the Czech Republic

  • 期刊论文

  • 发表日期：

    2025年5月27日

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  • Martin Chmel,
  • Petr Ježek,
  • Renata Šafránková,
  • Zuzana Ileninová,
  • Valentyna Vlasatá,
  • Lucia Mališová

摘要

The genus Escherichia comprises seven species, including Escherichia marmotae, described in 2015 from the feces of healthy Himalayan marmots (Marmota himalayana). This species exhibits atypical biochemical properties, such as negative lactose fermentation and indole production. The pathogenic potential of E. marmotae is demonstrated by its ability to invade epithelial cells and the presence of virulence genes. The first human infections with E. marmotae were recorded in Norway in 2021. This article describes the case of a 64-year-old man undergoing chemotherapy for urinary tract cancer, who was hospitalized with febrile neutropenia. An infection caused by E. marmotae and K. pneumoniae was detected. Laboratory diagnostics revealed a multidrug-resistant strain of E. coli producing KPC-type carbapenemase, subsequently identified as E. marmotae by MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry) and confirmed by 16S rRNA sequencing and whole genome sequencing. Biochemical tests indicated similarities to E. coli. Virulence analysis revealed the presence of genes typical of pathogenic strains of E. coli. This case report is the first documented instance of E. marmotae in the Czech Republic and highlights the difficulty of distinguishing this species from E. coli in routine diagnostics. Accurate identification requires advanced methods such as MALDI-TOF and sequencing analysis.