<p>The gut-kidney axis is the bidirectional relationship between the gut microbiota and the kidney function. Chronic inflammatory responses can impair kidney function and probiotics and postbiotics agents can have positive effects on gut health and kidney function by modulating inflammation through affecting autophagy signaling pathway. The aim of the current study was to evaluate the properties of our probiotic and postbiotics to improve kidney health by focusing the autophagy signaling pathway. The probiotic and postbiotics of four <i>Lactobacillus</i> and two <i>Bifidobacterium</i> strains were selected. Dextran sulfate sodium induced colitis in mice, and probiotics and postbiotics treatments were accomplished in animal experiment. A qPCR assay was performed to assess the gene expression involved in the autophagy process in the kidney. In contrast to the dextran sulfate sodium group, both the probiotic and postbiotics cocktails exhibited the capacity to inhibit colitis-associated indicators. Of note, the postbiotics cocktails demonstrated a greater efficacy in preventing colitis-related indicators and also it could display a more pronounced effect in upregulating autophagy-related genes. Our native potential probiotics and postbiotics can be able to reduce gut inflammation and cope with kidney inflammation by triggering autophagy signaling pathway through the considerable impact on gut-organ axis. There is an encouraging concept about the anti-inflammatory effects of our probiotics and postbiotics cocktails with least side effects as a supplementary treatment not only in the gut, but also in the other organs particularly kidneys.</p>