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<p>To develop a pH-responsive drug-releasing textile, a water-soluble cyclodextrin polymer (HCP) was synthesized and loaded with luteolin (Lut) to form an inclusion complex. This complex was immobilized onto cationized cotton via electrostatic adsorption and subsequent Ca<sup>2</sup>⁺ cross-linking. The resulting textile achieved a stable drug loading of 0.106&#xa0;mg/cm<sup>2</sup> while exhibiting high tensile strength (467.5&#xa0;N) and good water vapor permeability (1100&#xa0;g/m<sup>2</sup>). In vitro release studies demonstrated a pH-responsive mechanism with accelerated release in the acidic microenvironment (pH 5.5) compared to physiological pH 7.4. The functionalized textile displayed bacteriostatic activity against <i>S. aureus</i> and biocompatibility with L929 fibroblasts. Kinetic analysis indicated a diffusion-controlled release profile fitted to the Higuchi model, suggesting potential for smart wound-dressing applications.</p>

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A pH-Responsive Textile Functionalized with a Luteolin-Cyclodextrin Polymer Complex

  • 期刊论文

  • 发表日期：

    2026年1月19日

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  • Xiao-Zhu Sun,
  • Wan-Chang Chen,
  • Meng Wang

摘要

To develop a pH-responsive drug-releasing textile, a water-soluble cyclodextrin polymer (HCP) was synthesized and loaded with luteolin (Lut) to form an inclusion complex. This complex was immobilized onto cationized cotton via electrostatic adsorption and subsequent Ca2⁺ cross-linking. The resulting textile achieved a stable drug loading of 0.106 mg/cm2 while exhibiting high tensile strength (467.5 N) and good water vapor permeability (1100 g/m2). In vitro release studies demonstrated a pH-responsive mechanism with accelerated release in the acidic microenvironment (pH 5.5) compared to physiological pH 7.4. The functionalized textile displayed bacteriostatic activity against S. aureus and biocompatibility with L929 fibroblasts. Kinetic analysis indicated a diffusion-controlled release profile fitted to the Higuchi model, suggesting potential for smart wound-dressing applications.