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<p>Thermal-responsive shape-memory polymer fibers represent a promising candidate for controllable local drug delivery systems. In this study, we developed thermo-responsive shape-memory fibrous membranes through electrospinning and UV cross-linking, utilizing a blend of poly(p-dioxanone) (PPDO) and poly(ε-caprolactone) (PCL), which were loaded with doxorubicin (DOX). Scanning electron microscopy (SEM) characterization revealed the formation of three types of electrospun fibrous membranes with fiber diameters measuring 1.8 ± 0.4, 3.0 ± 0.7, and 3.7 ± 1.8 μm, designated as PDC-S, PDC-M, and PDC-L, respectively. The results indicated that the chains of PPDO and PCL are crosslinked by UV irradiation through benzophenone and triallyl isocyanurate. Specifically, PPDO functions as hard segments while PCL serves as switching segments. Further investigation demonstrated that the PDC-M membrane exhibited optimal performance with approximately 90% shape fixity ratio and around 82% recovery ratio alongside favorable mechanical properties. After programming, PDC-M displayed controllable drug release behavior capable of releasing DOX in a two-step manner under thermal stimulation. Consequently, they showed significantly enhanced antitumor efficacy along with improved drug-utilization efficiency. Therefore, the PDC membranes prepared through simple blending and UV crosslinking exhibit the desired shape-memory effect, demonstrating significant potential for local antitumor drug delivery applications.</p>

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UV-Crosslinked Electrospun Polymer Blends Based Fibrous Membranes With Desired Shape-Memory Effect for Controllable Local Drug Release

  • 期刊论文

  • 发表日期：

    2025年11月27日

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  • Xiaoying Luo,
  • Jun Yang,
  • Jiang Chen,
  • Xianzu Ling,
  • Jiayi Jiang,
  • Hao Lu,
  • Yizao Wan,
  • Quanchao Zhang

摘要

Thermal-responsive shape-memory polymer fibers represent a promising candidate for controllable local drug delivery systems. In this study, we developed thermo-responsive shape-memory fibrous membranes through electrospinning and UV cross-linking, utilizing a blend of poly(p-dioxanone) (PPDO) and poly(ε-caprolactone) (PCL), which were loaded with doxorubicin (DOX). Scanning electron microscopy (SEM) characterization revealed the formation of three types of electrospun fibrous membranes with fiber diameters measuring 1.8 ± 0.4, 3.0 ± 0.7, and 3.7 ± 1.8 μm, designated as PDC-S, PDC-M, and PDC-L, respectively. The results indicated that the chains of PPDO and PCL are crosslinked by UV irradiation through benzophenone and triallyl isocyanurate. Specifically, PPDO functions as hard segments while PCL serves as switching segments. Further investigation demonstrated that the PDC-M membrane exhibited optimal performance with approximately 90% shape fixity ratio and around 82% recovery ratio alongside favorable mechanical properties. After programming, PDC-M displayed controllable drug release behavior capable of releasing DOX in a two-step manner under thermal stimulation. Consequently, they showed significantly enhanced antitumor efficacy along with improved drug-utilization efficiency. Therefore, the PDC membranes prepared through simple blending and UV crosslinking exhibit the desired shape-memory effect, demonstrating significant potential for local antitumor drug delivery applications.