<p>The fiber-reinforced polymer composites obviously find inventive practice as modern materials for several structural and functional applications due to their high specific strength and stiffness. The interply hybrid composites are designated for their versatile performance in structural applications, replacing the conventional materials and offering more stable and durable alternatives. The importance of these hybrid composites lies in their ability to provide tailored mechanical, thermal, and electrical properties, which makes them an ideal substitute for harnessing a wide range of applications across diverse industries such as aerospace, automobiles, construction, etc. Nevertheless, ongoing improvements are required in hybrid composites, particularly in addressing deficiencies at the fiber-matrix interface. Further attention is required to investigate the delamination resistance and failure modes. The present work is an effort to develop hybrid fiber composites with both E-glass and S-glass incorporating the fibers of carbon and Kevlar. The study profoundly analyzes the effect of stacking sequences and Mode II delamination characteristics of the hybrid composites by using end-notched flexure specimen test. The study reveals that hybrid fibers made by using both E-glass and S-glass fibers have similar outcomes. There is no significant deviation between the two types of glass fibers. It is found that the inclusion of carbon fiber with glass fiber increases the stiffness nearly 100%, whereas the inclusion of Kevlar with glass increases only about 50% for both glass types. Glass–carbon fiber doubles the interlaminar toughness, shear strength, and stiffness, whereas glass–Kevlar fiber significantly lowers the toughness of the hybrid composite.</p>