We present the topological foundations for solvability of multiplicative Cousin problems formulated on an axially symmetric domain \(\Omega \subset \mathbb {H}.\) In particular, we provide a geometric construction of quaternionic Cartan coverings, which are generalizations of (complex) Cartan coverings as presented in Section 4 of Forstnerič and Prezelj (Math. Ann. 322(4), 633-666 (2002)). Because of the requirements of symmetry inherent to the domains of definition of quaternionic regular functions, the existence of quaternionic Cartan coverings of \(\Omega \) is not a consequence of the existence of complex Cartan coverings; for the latter, there are no requirements for the symmetries with respect to the real axis. Due to the real axis’s special role, also the covering restricted to \(\Omega \cap \mathbb {R}\) must have additional properties. All these required properties were achieved by starting from a particular symmetric tiling of the symmetric set \(\Omega \cap (\mathbb {R}+ i\mathbb {R})\) . Finally, we apply these results to prove the vanishing of ’antisymmetric’ cohomology groups of planar symmetric domains for \(n \ge 2\) .