Scholarlink

<p>Neutropenic patients with hematological malignancies are at high risk for infectious complications. Whether associated lymphopenia or hypogammaglobulinemia further increase this risk and affect outcome remains unclear. This retrospective single-center study included 321 patients hospitalized with lymphoma or leukemia and severe neutropenia whose serum immunoglobulin levels were measured. Overall, 60% of patients had isolated lymphopenia, 9% isolated hypogammaglobulinemia, 24% both, and 7% none. There was no correlation between absolute lymphocyte count and IgG. Severe lymphopenia was not associated with infection or mortality. Hypogammaglobulinemia was more prevalent in lymphoid leukemias and lymphomas. A multivariate logistic regression analysis adjusting for age, underlying hematological malignancy, absolute neutrophil and lymphocyte counts, and duration of neutropenia and lymphopenia showed that hypogammaglobulinemia was associated with infection (OR 1.85, 95% CI 1.07–3.26, <i>p</i> = 0.03), pneumonia (OR 2.04, 95% CI 1.13–3.72, <i>p</i> = 0.02), and sepsis or septic shock (OR 2.43, 95% CI 1.26–4.72, <i>p</i> = 0.01). This indicates a need for further investigation into the role of immunoglobulin replacement therapy in this setting.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of lymphopenia and hypogammaglobulinemia on outcomes in neutropenic patients with hematological malignancies

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月5日

查看全文
  • Andry Van de Louw,
  • Lauren King,
  • Myles Nickolich

摘要

Neutropenic patients with hematological malignancies are at high risk for infectious complications. Whether associated lymphopenia or hypogammaglobulinemia further increase this risk and affect outcome remains unclear. This retrospective single-center study included 321 patients hospitalized with lymphoma or leukemia and severe neutropenia whose serum immunoglobulin levels were measured. Overall, 60% of patients had isolated lymphopenia, 9% isolated hypogammaglobulinemia, 24% both, and 7% none. There was no correlation between absolute lymphocyte count and IgG. Severe lymphopenia was not associated with infection or mortality. Hypogammaglobulinemia was more prevalent in lymphoid leukemias and lymphomas. A multivariate logistic regression analysis adjusting for age, underlying hematological malignancy, absolute neutrophil and lymphocyte counts, and duration of neutropenia and lymphopenia showed that hypogammaglobulinemia was associated with infection (OR 1.85, 95% CI 1.07–3.26, p = 0.03), pneumonia (OR 2.04, 95% CI 1.13–3.72, p = 0.02), and sepsis or septic shock (OR 2.43, 95% CI 1.26–4.72, p = 0.01). This indicates a need for further investigation into the role of immunoglobulin replacement therapy in this setting.