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Recent Findings <p>Not applicable.</p> Summary <p>Pulsed field ablation (PFA) has been increasingly adopted for catheter ablation of atrial fibrillation, owing to its increased procedural efficiency when compared to radiofrequency ablation. Due to its non-thermal and relatively tissue-selective mechanism of action, PFA does not carry many of the traditional risks associated with thermal ablation,but real-world experience has shown that other non-traditional, PFA-specific ablation risks can occur. Among these, hemolysis, coronary artery involvement (spasm and fibrosis), and profound vagal responses have been increasingly reported when using this technology. Herein, we will review the current understanding of the pathophysiology, clinical implications, and prevention or treatment strategies for these PFA-specific ablation risks.</p>

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Avoiding Non-Traditional Ablation Risks with Pulse-Field Ablation for Atrial Fibrillation

  • 期刊论文

  • 发表日期：

    2025年9月27日

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  • Carola Gianni,
  • Vincenzo Mirco La Fazia,
  • Mohanad Elchouemi,
  • Bryan C. MacDonald,
  • Angel Quintero Mayedo,
  • Sanghamitra Mohanty,
  • John D. Allison,
  • Mohamed A. Bassiouny,
  • Weeranun D. Bode,
  • J. David Burkhardt,
  • Rodney P. Horton,
  • G. Joseph Gallinghouse,
  • Javier E. Sanchez,
  • Andrea Natale,
  • Amin Al-Ahmad

摘要

Recent Findings

Not applicable.

Summary

Pulsed field ablation (PFA) has been increasingly adopted for catheter ablation of atrial fibrillation, owing to its increased procedural efficiency when compared to radiofrequency ablation. Due to its non-thermal and relatively tissue-selective mechanism of action, PFA does not carry many of the traditional risks associated with thermal ablation,but real-world experience has shown that other non-traditional, PFA-specific ablation risks can occur. Among these, hemolysis, coronary artery involvement (spasm and fibrosis), and profound vagal responses have been increasingly reported when using this technology. Herein, we will review the current understanding of the pathophysiology, clinical implications, and prevention or treatment strategies for these PFA-specific ablation risks.