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<p>A molecularly imprinted polymer (MIP) coating for surface-enhanced Raman spectroscopy (SERS) was developed for the detection of sibutramine. Using sibutramine as the template, methyl methacrylate as the functional monomer, 1,4-butanediol dimethacrylate as the cross-linker, and phenylsilane as the initiator, MIPs were synthesized via molecular imprinting on silver nanorod–coated copper rods. The coating specifically recognizes sibutramine in complex matrices such as milk tea. The characteristic peak intensity is proportional to concentration over a linear range of 5–500&#xa0;ng/mL, with a detection limit of 2&#xa0;ng/mL. Recoveries for spiked samples ranged from 96.60 to 99.08% with a relative standard deviation of 2.64–8.67%, consistent with HPLC results. The coating exhibits dual functionality: It specifically recognizes and adsorbs sibutramine, and it is reusable. This work presents a novel SERS method for detecting sibutramine in diet foods, offering an accurate, low-cost, and highly selective approach for analyzing complex food systems.</p>

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Synergistic Enhancement of SERS Sensors Based on Silver Nanorods@MIPs for Rapid and Sensitive Detection of Sibutramine in Food

  • 期刊论文

  • 发表日期：

    2026年6月3日

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  • Jing Neng,
  • Jimei Yu,
  • Qian Guo,
  • Yazhi Wang,
  • Yan Wang,
  • Yilong Zhang,
  • Peng Chen,
  • Kai Yang

摘要

A molecularly imprinted polymer (MIP) coating for surface-enhanced Raman spectroscopy (SERS) was developed for the detection of sibutramine. Using sibutramine as the template, methyl methacrylate as the functional monomer, 1,4-butanediol dimethacrylate as the cross-linker, and phenylsilane as the initiator, MIPs were synthesized via molecular imprinting on silver nanorod–coated copper rods. The coating specifically recognizes sibutramine in complex matrices such as milk tea. The characteristic peak intensity is proportional to concentration over a linear range of 5–500 ng/mL, with a detection limit of 2 ng/mL. Recoveries for spiked samples ranged from 96.60 to 99.08% with a relative standard deviation of 2.64–8.67%, consistent with HPLC results. The coating exhibits dual functionality: It specifically recognizes and adsorbs sibutramine, and it is reusable. This work presents a novel SERS method for detecting sibutramine in diet foods, offering an accurate, low-cost, and highly selective approach for analyzing complex food systems.