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<p><i>Ganoderma</i> is a multi-species fungal genus of economic importance with various health-promoting effects. It is widely used as an ingredient for dietary supplements, functional foods, or medicines globally. Triterpenoids are the main bioactive components responsible for the therapeutic and pharmacological properties of <i>Ganoderma</i>. This study investigated the triterpenoid profiles of fruiting bodies of <i>Ganoderma lucidum</i> (GL), <i>Ganoderma japonicum</i> (GJ), <i>Ganoderma applanatum</i> (GA), and <i>Ganoderma tsugae</i> (GT), as well as commercial mycelium biomass products. Thirty-five fruiting body samples and eight mycelium biomass samples obtained from the American Herbal Pharmacopoeia (Soquel, CA) were analyzed using ultra-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) combined with molecular networking. A total of 93 compounds including 88 triterpenoids were detected and tentatively identified in the fruiting bodies. In contrast, no triterpenoids were detected in the mycelium biomass samples under the same analytical conditions. Among the fruiting bodies, inconsistent chemical profiles were observed both between <i>Ganoderma</i> species, and among samples labeled as the same species, particularly within GL. The results of this study indicate that evaluating the triterpenoid profiles of samples is very important for quality control. The triterpenoid profiles among different <i>Ganoderma</i> species revealed in this study may help species identification and authentication in future studies.</p>

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Studying the Triterpenoid Profiles of Four Ganoderma Species Using UHPLC-HRMS-Based Metabolomics and Molecular Networking

  • 期刊论文

  • 发表日期：

    2026年4月28日

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  • Yanfang Li,
  • Roy Upton,
  • Mengliang Zhang,
  • Ping Geng,
  • Pei Chen

摘要

Ganoderma is a multi-species fungal genus of economic importance with various health-promoting effects. It is widely used as an ingredient for dietary supplements, functional foods, or medicines globally. Triterpenoids are the main bioactive components responsible for the therapeutic and pharmacological properties of Ganoderma. This study investigated the triterpenoid profiles of fruiting bodies of Ganoderma lucidum (GL), Ganoderma japonicum (GJ), Ganoderma applanatum (GA), and Ganoderma tsugae (GT), as well as commercial mycelium biomass products. Thirty-five fruiting body samples and eight mycelium biomass samples obtained from the American Herbal Pharmacopoeia (Soquel, CA) were analyzed using ultra-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) combined with molecular networking. A total of 93 compounds including 88 triterpenoids were detected and tentatively identified in the fruiting bodies. In contrast, no triterpenoids were detected in the mycelium biomass samples under the same analytical conditions. Among the fruiting bodies, inconsistent chemical profiles were observed both between Ganoderma species, and among samples labeled as the same species, particularly within GL. The results of this study indicate that evaluating the triterpenoid profiles of samples is very important for quality control. The triterpenoid profiles among different Ganoderma species revealed in this study may help species identification and authentication in future studies.