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<p>Ziziphi Spinosae Semen (ZSS) is the seed of <i>Ziziphus jujuba</i> Mill. var. <i>spinosa</i> (Bunge) Hu ex H. F. Chou. As a food and medicine homologous herbal medicine, it was extensively employed to treat insomnia for the safety and significant therapeutic effects. To establish a comprehensive quality evaluation method for ZSS, this study proposed an integrated strategy combining chemometrics and weighted TOPSIS-GRA fusion model. Ultra-high performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF–MS) was employed to identify 96 chemical components in ZSS. Thereafter, a high-performance liquid chromatography-triple quadrupole tandem mass spectrometry (HPLC-QQQ-MS/MS) method was developed for the simultaneous quantification of 22 compounds. Multivariate statistical analysis was applied to compare different batches of ZSS samples, and a multi-index comprehensive evaluation system was constructed by the technique for order preference by similarity to ideal solution (TOPSIS) and gray correlation analysis (GRA) fusion model analysis to achieve quantitative ranking and grading of ZSS quality. The results demonstrated that this strategy could effectively evaluate the quality differences of ZSS and identify six key differential markers, including magnoflorine, 6‴-feruloylspinosin, jujuboside A, jujuboside B, spinosin, and frangufoline. The comprehensive evaluation model developed in this study can provide reference for the quality control and standardization of ZSS.</p>

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An Integrative Strategy on the Quality Evaluation of Ziziphi Spinosae Semen Based on Combing Chemometrics and Weighted TOPSIS-GRA Fusion Model

  • 期刊论文

  • 发表日期：

    2025年12月29日

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  • Wenhan Lin,
  • Zijing Zhang,
  • Shuting Zhou,
  • Jinyue Ma,
  • Ye Shang,
  • Zhenguo Lv,
  • Lu Chen,
  • Kaili Zhang,
  • Wenwen Li,
  • Yameng Zhu,
  • Huizi Ouyang,
  • Jun He

摘要

Ziziphi Spinosae Semen (ZSS) is the seed of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou. As a food and medicine homologous herbal medicine, it was extensively employed to treat insomnia for the safety and significant therapeutic effects. To establish a comprehensive quality evaluation method for ZSS, this study proposed an integrated strategy combining chemometrics and weighted TOPSIS-GRA fusion model. Ultra-high performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF–MS) was employed to identify 96 chemical components in ZSS. Thereafter, a high-performance liquid chromatography-triple quadrupole tandem mass spectrometry (HPLC-QQQ-MS/MS) method was developed for the simultaneous quantification of 22 compounds. Multivariate statistical analysis was applied to compare different batches of ZSS samples, and a multi-index comprehensive evaluation system was constructed by the technique for order preference by similarity to ideal solution (TOPSIS) and gray correlation analysis (GRA) fusion model analysis to achieve quantitative ranking and grading of ZSS quality. The results demonstrated that this strategy could effectively evaluate the quality differences of ZSS and identify six key differential markers, including magnoflorine, 6‴-feruloylspinosin, jujuboside A, jujuboside B, spinosin, and frangufoline. The comprehensive evaluation model developed in this study can provide reference for the quality control and standardization of ZSS.