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<p>In the detection of quinolone residues in freshwater shrimp across various regions of China, more samples were found to contain residues of the banned drug norfloxacin using liquid chromatography-quadrupole tandem mass spectrometry (LC-QQQ). To further validate these results, three qualitative methods were developed: optimized LC-QQQ, liquid chromatography-quadrupole linear ion trap tandem mass spectrometry (LC-Qtrap), and liquid chromatography-quadrupole electrostatic field orbital trap tandem mass spectrometry (LC-Q Exactive). The optimized LC-QQQ involved adjusting the mobile phase gradient and monitoring specific ions, while LC-Qtrap utilized enhanced ion scanning (EPI) mode. For LC-Q Exactive, the full MS-dd-MS<sup>2</sup> mode was applied. After review, all suspected samples were excluded due to the potential interference from an endogenous substance in the shrimp that has a similar mass to norfloxacin. Each method has distinct features and can be employed as a qualitative method in different laboratory settings, offering robust technical support for food safety oversight.</p>

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Comparative Study of One Detection and Three Confirmation LC-MS Methods for Norfloxacin in Freshwater Shrimp

  • 期刊论文

  • 发表日期：

    2025年11月21日

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  • Lian Wang,
  • Chunying Luo,
  • Xin Ning,
  • Shu Zhang,
  • Wenqian Hou

摘要

In the detection of quinolone residues in freshwater shrimp across various regions of China, more samples were found to contain residues of the banned drug norfloxacin using liquid chromatography-quadrupole tandem mass spectrometry (LC-QQQ). To further validate these results, three qualitative methods were developed: optimized LC-QQQ, liquid chromatography-quadrupole linear ion trap tandem mass spectrometry (LC-Qtrap), and liquid chromatography-quadrupole electrostatic field orbital trap tandem mass spectrometry (LC-Q Exactive). The optimized LC-QQQ involved adjusting the mobile phase gradient and monitoring specific ions, while LC-Qtrap utilized enhanced ion scanning (EPI) mode. For LC-Q Exactive, the full MS-dd-MS2 mode was applied. After review, all suspected samples were excluded due to the potential interference from an endogenous substance in the shrimp that has a similar mass to norfloxacin. Each method has distinct features and can be employed as a qualitative method in different laboratory settings, offering robust technical support for food safety oversight.