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<p>Deep brain stimulation (DBS) has emerged as a promising therapeutic intervention for individuals with treatment-resistant post-traumatic stress disorder (PTSD). However, the ethical acceptability of DBS as a neurointervention remains a subject of considerable debate. These concerns include the reliability of therapeutic efficacy, the evaluation of safety risks, the adequacy of informed consent processes, and the potential effects of DBS on personality, identity, agency, authenticity, autonomy, and self (PIAAAS). Moreover, current ethical assessments of DBS for PTSD may neglect cultural sensitivity, despite substantial cross-cultural differences in how therapeutic benefits are perceived, how traumatic memories are valued, and how personal change is understood, as illustrated in contexts such as the United States, Western Europe, Japan, and China. Therefore, to ensure the ethical application of DBS for PTSD, it is imperative to develop an evidence-based and culturally sensitive normative framework to guide clinical practice, striking a balance between the subjective pursuit of personal well-being and the objective demands of cultural norms.</p>

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Ethical Challenges of Deep Brain Stimulation for Post-Traumatic Stress Disorder: Evidence Gaps and Cultural Sensitivities

  • 期刊论文

  • 发表日期：

    2026年3月27日

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  • Junjie Yang

摘要

Deep brain stimulation (DBS) has emerged as a promising therapeutic intervention for individuals with treatment-resistant post-traumatic stress disorder (PTSD). However, the ethical acceptability of DBS as a neurointervention remains a subject of considerable debate. These concerns include the reliability of therapeutic efficacy, the evaluation of safety risks, the adequacy of informed consent processes, and the potential effects of DBS on personality, identity, agency, authenticity, autonomy, and self (PIAAAS). Moreover, current ethical assessments of DBS for PTSD may neglect cultural sensitivity, despite substantial cross-cultural differences in how therapeutic benefits are perceived, how traumatic memories are valued, and how personal change is understood, as illustrated in contexts such as the United States, Western Europe, Japan, and China. Therefore, to ensure the ethical application of DBS for PTSD, it is imperative to develop an evidence-based and culturally sensitive normative framework to guide clinical practice, striking a balance between the subjective pursuit of personal well-being and the objective demands of cultural norms.