Scholarlink

Objective <p><sup>15</sup>O-gas positron emission tomography (PET), which enables quantitative assessment of cerebral blood flow and oxygen metabolism, is widely performed to diagnose cerebrovascular disorders and evaluate therapeutic effects. While the autoradiography method offers high quantitative accuracy, short restraint time, and reduced radiation exposure as advantages over the steady-state method, it requires several radiation detectors in addition to a PET scanner. In contrast, PET/CT systems optimized for whole-body tumor imaging with <sup>18</sup>F-2-deoxy-2-fluoro-D-glucose have high sensitivity, and recent regulatory developments have facilitated active efforts to reduce radiation dose through low-dose administration. Dose reduction is desirable for <sup>15</sup>O-gas PET, which involves the inhalation of relatively high radioactivity concentrations; nonetheless, obtaining an arterial input function with sufficient statistical precision is challenging under low-dose conditions. In this study, we aimed to investigate how variations in the crosscalibration factor between the dose calibrator and the continuous blood-sampling system (CCFcbs), as well as the magnitude of statistical noise in the arterial input function measured using the continuous blood-sampling system (aTACnoise), affect the quantitative parameters of cerebral blood flow and oxygen metabolism images.</p> Methods <p>Ten patients with cerebrovascular disease (six men and four women) with a median age of 61.5 years were enrolled. The effects of CCFcbs and aTACnoise on quantitative cerebral hemodynamic and metabolic parameters were evaluated.</p> Results <p>Cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) showed an inverse correlation with CCFcbs; however, the oxygen extraction fraction (OEF) was minimally affected. aTACnoise had a greater impact on OEF and CMRO2 than on CBF, and the variability increased as statistical precision decreased.</p> Conclusions <p>A highly sensitive continuous blood-sampling system or technical improvements that enable higher-sensitivity measurements are crucial for obtaining an arterial input function with sufficient statistical precision. Furthermore, standardization of the calibration procedure is essential.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Error analysis of cerebral blood flow and oxygen metabolism in three-dimensional 15O-gas positron emission tomography acquisition

  • 期刊论文

  • 发表日期：

    2026年4月27日

查看全文
  • Keiji Shimizu,
  • Keiichi Matsumoto,
  • Wataru Omasa,
  • Go Akamatsu,
  • Yasuhiko Ikari,
  • Masahiro Sasaki,
  • Takeharu Ibaraki,
  • Michio Senda,
  • Tomohiko Yamane

摘要

Objective

15O-gas positron emission tomography (PET), which enables quantitative assessment of cerebral blood flow and oxygen metabolism, is widely performed to diagnose cerebrovascular disorders and evaluate therapeutic effects. While the autoradiography method offers high quantitative accuracy, short restraint time, and reduced radiation exposure as advantages over the steady-state method, it requires several radiation detectors in addition to a PET scanner. In contrast, PET/CT systems optimized for whole-body tumor imaging with 18F-2-deoxy-2-fluoro-D-glucose have high sensitivity, and recent regulatory developments have facilitated active efforts to reduce radiation dose through low-dose administration. Dose reduction is desirable for 15O-gas PET, which involves the inhalation of relatively high radioactivity concentrations; nonetheless, obtaining an arterial input function with sufficient statistical precision is challenging under low-dose conditions. In this study, we aimed to investigate how variations in the crosscalibration factor between the dose calibrator and the continuous blood-sampling system (CCFcbs), as well as the magnitude of statistical noise in the arterial input function measured using the continuous blood-sampling system (aTACnoise), affect the quantitative parameters of cerebral blood flow and oxygen metabolism images.

Methods

Ten patients with cerebrovascular disease (six men and four women) with a median age of 61.5 years were enrolled. The effects of CCFcbs and aTACnoise on quantitative cerebral hemodynamic and metabolic parameters were evaluated.

Results

Cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) showed an inverse correlation with CCFcbs; however, the oxygen extraction fraction (OEF) was minimally affected. aTACnoise had a greater impact on OEF and CMRO2 than on CBF, and the variability increased as statistical precision decreased.

Conclusions

A highly sensitive continuous blood-sampling system or technical improvements that enable higher-sensitivity measurements are crucial for obtaining an arterial input function with sufficient statistical precision. Furthermore, standardization of the calibration procedure is essential.