Objective 177Lu-DOTATATE and 177Lu-PSMA-617 used as therapeutic radiopharmaceuticals are primarily excreted in urine and may cause relatively high levels of contamination in toilets and sink areas. This study aimed to comprehensively evaluate a novel fluorine-coated film as a practical solution for the management of 177Lu-DOTATATE contamination by (1) quantifying its decontamination efficiency, (2) assessing its effectiveness in clinical settings, and (3) identifying optimal applications in nuclear medicine facilities. Methods The developed hydrophobic films [fluorine-coated film (F-film) and fluorine-urethane resin-coated film (FU-film)] were prepared along with a commercial hydrophobic film (Aquaglide), stainless-steel plate, sink, and urine bag were used as the test materials. Contact angles were measured using the sessile-drop method. The relationship between the contact angle of each test material (excluding the sink) and the count reduction rate after applying 177Lu-DOTATATE (4.93 Bq/ml, 0.1 ml) was investigated. Each measurement was performed three times. To confirm the effectiveness in a clinical setting, the FU-film was applied to a toilet bowl, and the contamination after urination by patients who were administered 177Lu-DOTATATE was evaluated. Results A strong positive correlation (r = 0.84, p = 0.001) was observed between the contact angle of the test material surface and the reduction rate of the count after wiping with a wet paper towel. Specifically, the counts of the F-film, FU-film, and Aquaglide, which had contact angles greater than 90°, decreased by 92.1%, 96.8%, and 97.4%, respectively, and the counts on the sink and the stainless-steel plate decreased by 71.9% and 69.2%, respectively. The count of the FU-film was 23.3% lower than that of the urine bag. The density of surface contamination of the FU-film after flushing was 62.2% lower than that of the toilet bowl and was lower than the background level. Conclusion The developed FU-film effectively prevents and reduces 177Lu-DOTATATE contamination, with a reduction rate as high as 96.8%. This is particularly useful for protecting areas where water flows directly, such as sinks and toilet bowls, and also for protecting other medical materials that may be contaminated with urine.

Clinical evaluation of fluorine-urethane resin-coated films for preventing and managing ¹⁷⁷Lu-DOTATATE surface contamination

期刊论文
发表日期：

2025年6月23日

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Katsuya Okuhata,
Hajime Monzen,
Go Takai,
Makoto Hosono

摘要

Objective

¹⁷⁷Lu-DOTATATE and ¹⁷⁷Lu-PSMA-617 used as therapeutic radiopharmaceuticals are primarily excreted in urine and may cause relatively high levels of contamination in toilets and sink areas. This study aimed to comprehensively evaluate a novel fluorine-coated film as a practical solution for the management of ¹⁷⁷Lu-DOTATATE contamination by (1) quantifying its decontamination efficiency, (2) assessing its effectiveness in clinical settings, and (3) identifying optimal applications in nuclear medicine facilities.

Methods

The developed hydrophobic films [fluorine-coated film (F-film) and fluorine-urethane resin-coated film (FU-film)] were prepared along with a commercial hydrophobic film (Aquaglide), stainless-steel plate, sink, and urine bag were used as the test materials. Contact angles were measured using the sessile-drop method. The relationship between the contact angle of each test material (excluding the sink) and the count reduction rate after applying ¹⁷⁷Lu-DOTATATE (4.93 Bq/ml, 0.1 ml) was investigated. Each measurement was performed three times. To confirm the effectiveness in a clinical setting, the FU-film was applied to a toilet bowl, and the contamination after urination by patients who were administered ¹⁷⁷Lu-DOTATATE was evaluated.

Results

A strong positive correlation (r = 0.84, p = 0.001) was observed between the contact angle of the test material surface and the reduction rate of the count after wiping with a wet paper towel. Specifically, the counts of the F-film, FU-film, and Aquaglide, which had contact angles greater than 90°, decreased by 92.1%, 96.8%, and 97.4%, respectively, and the counts on the sink and the stainless-steel plate decreased by 71.9% and 69.2%, respectively. The count of the FU-film was 23.3% lower than that of the urine bag. The density of surface contamination of the FU-film after flushing was 62.2% lower than that of the toilet bowl and was lower than the background level.

Conclusion

The developed FU-film effectively prevents and reduces ¹⁷⁷Lu-DOTATATE contamination, with a reduction rate as high as 96.8%. This is particularly useful for protecting areas where water flows directly, such as sinks and toilet bowls, and also for protecting other medical materials that may be contaminated with urine.

Clinical evaluation of fluorine-urethane resin-coated films for preventing and managing 177Lu-DOTATATE surface contamination

摘要

Clinical evaluation of fluorine-urethane resin-coated films for preventing and managing ¹⁷⁷Lu-DOTATATE surface contamination