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Objective <p>To explore the feasibility of a low-dose <sup>18</sup>F-FDG protocol for&#xa0;the&#xa0;30-cm standard axial field of view (SAFOV) PET/CT imaging in pediatric patients.</p> Methods <p>A retrospective analysis was conducted on 112 pediatric patients who underwent a full-dose (3.7&#xa0;MBq/kg) <sup>18</sup>F-FDG PET/CT imaging, and a prospective analysis was performed on 55 patients who received a low-dose (2.5&#xa0;MBq/kg) imaging. PET images were reconstructed at 1.0-min/bed intervals, and labeled as G1.0, G2.0, G3.0 for the&#xa0;full-dose imaging and G1.0', G2.0', G3.0' for&#xa0;the low-dose imaging. Patients were categorized into three age groups, and the image quality was assessed using the Likert scale and signal-to-noise ratio (SNR); Lesion detectability was evaluated using lesion detection rates and the target-to-liver ratio (TLR).</p> Results <p>In G2.0 and G3.0, all cases (112/112) achieved an image score of ≥ 3 and a lesion detection rate of 100% (98/98). There were no significant differences in SNR between G2.0 and G3.0 (11.09 ± 2.31 vs. 11.88 ± 2.58, <i>p</i> = 0.39), nor between age groups ≤ 5&#xa0;years and 6–10&#xa0;years groups (9.52 ± 3.16 vs. 9.53 ± 3.19, <i>p</i> = 0.99). In G3.0', 98.2% of cases (54/55) had an image score ≥ 3 and a lesion detection rate of 100% (43/43). The SNR of every age group for G3.0' was comparable to that of G2.0, and no significant differences between ≤ 5&#xa0;years and 6–10&#xa0;years groups (9.32 ± 1.94 vs. 9.99 ± 2.28, <i>p</i> = 0.82).</p> Conclusions <p>A 2.5&#xa0;MBq/kg dose with a 3.0&#xa0;min/bed acquisition protocol is feasible for <sup>18</sup>F-FDG 30-cm SAFOV PET/CT imaging in pediatric patients, and SNR and TLR demonstrated age-dependent discrepancies.</p>

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A low-dose protocol in pediatric 18F-FDG scans using 30-cm axis field of view PET/CT

  • 期刊论文

  • 发表日期：

    2025年2月28日

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  • Ha Wu,
  • Guobing Liu,
  • Xiemei Ruan,
  • Biying Zhang,
  • Zheng Zhe,
  • Hongcheng Shi

摘要

Objective

To explore the feasibility of a low-dose 18F-FDG protocol for the 30-cm standard axial field of view (SAFOV) PET/CT imaging in pediatric patients.

Methods

A retrospective analysis was conducted on 112 pediatric patients who underwent a full-dose (3.7 MBq/kg) 18F-FDG PET/CT imaging, and a prospective analysis was performed on 55 patients who received a low-dose (2.5 MBq/kg) imaging. PET images were reconstructed at 1.0-min/bed intervals, and labeled as G1.0, G2.0, G3.0 for the full-dose imaging and G1.0', G2.0', G3.0' for the low-dose imaging. Patients were categorized into three age groups, and the image quality was assessed using the Likert scale and signal-to-noise ratio (SNR); Lesion detectability was evaluated using lesion detection rates and the target-to-liver ratio (TLR).

Results

In G2.0 and G3.0, all cases (112/112) achieved an image score of ≥ 3 and a lesion detection rate of 100% (98/98). There were no significant differences in SNR between G2.0 and G3.0 (11.09 ± 2.31 vs. 11.88 ± 2.58, p = 0.39), nor between age groups ≤ 5 years and 6–10 years groups (9.52 ± 3.16 vs. 9.53 ± 3.19, p = 0.99). In G3.0', 98.2% of cases (54/55) had an image score ≥ 3 and a lesion detection rate of 100% (43/43). The SNR of every age group for G3.0' was comparable to that of G2.0, and no significant differences between ≤ 5 years and 6–10 years groups (9.32 ± 1.94 vs. 9.99 ± 2.28, p = 0.82).

Conclusions

A 2.5 MBq/kg dose with a 3.0 min/bed acquisition protocol is feasible for 18F-FDG 30-cm SAFOV PET/CT imaging in pediatric patients, and SNR and TLR demonstrated age-dependent discrepancies.